Results 81 to 90 of about 6,839 (207)

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. [PDF]

, 2014
Insulin and adrenergic stimulation are two divergent regulatory systems that may interact under certain pathophysiological circumstances. Here, we characterized a complex consisting of insulin receptor (IR) and β2-adrenergic receptor (β2AR) in the heart.
Abel, E Dale, Chen, Xiongwen, Clark, Richard B, Fu, Qin, Li, Jing, Li, Ying, Liu, Yongming, Parikh, Dippal, Rawlings, Tenley, Riehle, Christian, Shi, Qian, Xiang, Yang K, Xu, Bing, Zhang, Yuan, Zhu, Yi   +14 more
core   +2 more sources

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins

Cell Reports, 2015
The pacemaker properties of the suprachiasmatic nucleus (SCN) circadian clock are shaped by mechanisms that influence the expression and behavior of clock proteins.
Neel Mehta, Arthur H. Cheng, Cheng-Kang Chiang, Lucia Mendoza-Viveros, Harrod H. Ling, Abhilasha Patel, Bo Xu, Daniel Figeys, Hai-Ying M. Cheng   +8 more
doaj   +1 more source

G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy. [PDF]

, 2015
BACKGROUND: Takotsubo cardiomyopathy (TTC) is an increasingly reported clinical syndrome that mimics acute myocardial infarction without obstructive coronary artery disease and is characterized by transient systolic dysfunction of the apical and/or ...
Arvigo, L, ASSENNATO, Pasquale, Bova, M, Evola, S, Giambanco, F, Giambanco, S, Guglielmo, M, LIO, Domenico, NOVO, Giuseppina, NOVO, Salvatore, Sutera, MR, VACCARINO, Loredana   +11 more
core   +1 more source

G‐protein coupled receptor kinase 2(GRK2) is involved in μ‐receptor signaling in the mouse ileum but not colon

The FASEB Journal, 2008
Repeated administration of morphine results in tolerance to antinociception but not constipation. Tolerance develops to the effects of morphine in the ileum but not the colon. The objective of this study was to identify the intracellular signaling mechanisms responsible for these differences in these two organs.
Gracious R Ross, Bichoy R Gabra, William L Dewey, Hamid I Akbarali   +3 more
openaire   +1 more source

GRK2 activates TRAF2–NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis

Acta Pharmaceutica Sinica B
G protein-coupled receptor kinase 2 (GRK2) participates in the phosphorylation and desensitization of G protein-coupled receptor (GPCR), impacting various biological processes such as inflammation and cell proliferation.
Chenchen Han, Liping Jiang, Weikang Wang, Shujun Zuo, Jintao Gu, Luying Chen, Zhuo Chen, Jiajie Kuai, Xuezhi Yang, Liang Xu, Yang Ma, Wei Wei   +11 more
doaj   +1 more source

β2-adrenergic receptor promotes liver regeneration partially through crosstalk with c-met

Cell Death and Disease, 2022
The β2-adrenergic receptor (β2AR) is a G protein-coupled receptor (GPCR) that mediates the majority of cellular responses to external stimuli. Aberrant expression of β2AR results in various pathophysiological disorders, including tumorigenesis, but ...
Xiang Tao, Can Chen, Yingxiang Chen, Luoying Zhang, Jiong Hu, Hongjun Yu, Minglu Liang, Qin Fu, Kai Huang   +8 more
doaj   +1 more source

Expression Analysis of Selected microRNAs in Diabetes Mellitus Visceral Fat Tissues

Journal of Obesity, Volume 2026, Issue 1, 2026.
Purpose MicroRNA (miRNA) profiling of visceral adipose tissue in Type‐2 diabetes mellitus (T2DM) remains limited. We compared the expression of obesity‐associated miRNAs in visceral fat from individuals with T2DM versus metabolically healthy obesity (MHO) and examined Raf kinase inhibitory protein (RKIP) as a candidate miR‐543 target.
Rabeah Al-Temaimi, Rasheed Ahmad, Kusum Kapila, Fahd Al-Mulla, Claire Stocker   +4 more
wiley   +1 more source