Results 81 to 90 of about 37,211,421 (159)

Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

, 2016
G protein-coupled receptor kinase 2 (GRK2) is a pharmaceutical target for the treatment of cardiovascular diseases such as congestive heart failure, myocardial infarction, and hypertension.
Valerie M. Tesmer (2316499), Henning Steinhagen (2316505), Jochen Huber (2316502), David T. Lodowski (1305096), John J. G. Tesmer (488786)   +4 more
core   +1 more source

Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure.

, 2014
BACKGROUND: Increased cardiac G protein-coupled receptor kinase-2 (GRK2) expression has a pivotal role at inducing heart failure (HF)-related β-adrenergic receptor (βAR) dysfunction.
Liccardo, D., Marciano, C., Parisi, V., Furgi, G., P. P. Filardi, GALASSO, GENNARO, Giallauria, F., Furgi, Giuseppe, Liccardo, Daniela, GIALLAURIA, FRANCESCO, G. Furgi, Filardi, P.P., Ferrara, N., PARISI, VALENTINA, FEMMINELLA, GRAZIA DANIELA, de Lucia, Claudio, LEOSCO, DARIO, W. J. Koch, Zincarelli, Carmela, Vigorito, C., A. Cannavo, VIGORITO, CARLO, RENGO, GIUSEPPE, Cannavo, Alessandro, Filardi, Pasquale Perrone, Zincarelli, C., MARCIANO, CATERINA, Koch, W.J., FERRARA, NICOLA, Galasso, G., C. Zincarelli, D. Liccardo, Koch, Walter J., de Lucia, C., C. D. Lucia, Pagano, G., Leosco, D., PAGANO, GENNARO, PERRONE FILARDI, PASQUALE, Rengo, G., Cannavo, A., Femminella, Grazia D., Femminella, G.D.   +42 more
core   +1 more source

Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis

Scientific Reports, 2017
Despite the associations between diabetic complications and vascular endothelial dysfunction, a direct therapeutic method targeting endothelial dysfunction remains poorly characterized.
Kumiko Taguchi, Mari Hida, Mami Hasegawa, Haruka Narimatsu, Takayuki Matsumoto, Tsuneo Kobayashi   +5 more
doaj   +1 more source

Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2

Frontiers in Pharmacology, 2019
Hyperaldosteronism alters cardiac function, inducing adverse left ventricle (LV) remodeling either via increased fibrosis deposition, mitochondrial dysfunction, or both.
Alessandro Cannavo, Alessandro Cannavo, Federica Marzano, Andrea Elia, Daniela Liccardo, Leonardo Bencivenga, Giuseppina Gambino, Claudia Perna, Antonio Rapacciuolo, Antonio Cittadini, Nicola Ferrara, Nicola Ferrara, Nazareno Paolocci, Nazareno Paolocci, Walter J. Koch, Giuseppe Rengo, Giuseppe Rengo   +16 more
doaj   +1 more source

Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure

JACC: Basic to Translational Science
Summary: GRK2 is the most prominent G protein-coupled receptor kinase that is upregulated in heart failure (HF), and inhibiting GRK2 has improved cardiac function in mice.
Rajika Roy, PhD, Sarah M. Schumacher, PhD, Haley Christine Murphy, BS, Jessica Grondolsky, Thiele Osvaldt Rosales, PhD, J. Kurt Chuprun, PhD, Erhe Gao, MD, PhD, Huaqing Zhao, PhD, MS, Remus M. Berretta, BS, Alexander R.H. Hobby, PhD, Steven R. Houser, PhD, Larisa V. Avramova, PhD, John J.G. Tesmer, PhD, Walter J. Koch, PhD   +13 more
doaj   +1 more source

Fever-like temperature modification differentially affects in vitro signaling of bradykinin B-1 and B-2 receptors [PDF]

, 2011
The bradykinin (BK) B-2 and B-1 receptors (B2R, B1R) belong to the rhodopsin-like G protein-coupled receptors (GPCRs) and are involved in (patho)physiological processes such as blood pressure regulation or inflammation.
Dinkel, Klaus, Faussner, Alexander, Marianne Jochum, Jasmin Leschner, Alexander Faussner, Jochum, Marianne, Leschner, Jasmin, Larisa Ring, Ring, Larisa, Jens Feierler, Feierler, Jens, Klaus Dinkel   +11 more
core   +1 more source

Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family

FEBS Open Bio, 2019
Homologous domains embedded in multidomain proteins of different domain architectures (DA) may exhibit subtle, but important, differences in their structure and function.
Nagarajan Naveenkumar, Ramanathan Sowdhamini, Narayanaswamy Srinivasan   +2 more
doaj   +1 more source

Baicalin and ginsenoside Rb1 regulate the expression of adipocyte GRK2 and browning markers under lipid overload [PDF]

Exploration of Endocrine and Metabolic Diseases
Aim: Baicalin and ginsenoside Rb1 show the ability to promote adipocyte browning, but their effects, especially combined treatment, and the related mechanisms under pathological conditions are less known. The study investigated the regulation of browning
Zhuqi Wang, Jiayi Lao, Ziqing Wang, Honglei Zhang, Xinhong Shi, Kang Liu   +5 more
doaj   +1 more source

Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors

, 2013
G protein-coupled receptor kinase 2 (GRK2) is a relevant signaling node of the cellular transduction network, playing major roles in the physiology of various organs/tissues including the heart and blood vessels.
P. Campiglia, IACCARINO, Guido, CAMPIGLIA, Pietro, CIPOLLETTA, ERSILIA, Daniela Sorriento, SALA, MARINA, Antonio Limatola, CAROTENUTO, ALFONSO, M. Sala, G. Iaccarino, S. Musella, GOMEZ MONTERREY, ISABEL MARIA, D. Sorriento, VERNIERI, ERMELINDA, LIMATOLA, ANTONIO, Bruno Trimarco, Ettore Novellino, Ersilia Cipolletta, BERTAMINO, Alessia, GRIECO, PAOLO, Alfonso Carotenuto, NOVELLINO, ETTORE, E. Vernieri, Isabel Gomez Monterrey, Paolo Grieco, A. Bertamino, TRIMARCO, BRUNO, MUSELLA, SIMONA   +27 more
core   +1 more source

Regulation of the epithelial Na(+) channel by the RH domain of G protein-coupled receptor kinase, GRK2, and G alpha q/11

, 2011
The G protein-coupled receptor kinase (GRK2) belongs to a family of protein kinases that phosphorylates agonist-activated G protein-coupled receptors, leading to G protein-receptor uncoupling and termination of G protein signaling.
Il-Ha Lee, Cook, D., Lee, I., Campbell, C., David I. Cook, Anuwat Dinudom, Dinudom, A., Kumar, S., Sung-Hee Song, Song, S., Craig R. Campbell, Sharad Kumar   +11 more
core   +1 more source