Results 91 to 100 of about 6,839 (207)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, Volume 19, Issue 12, Page 3706-3728, December 2025.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death.

PLoS Pathogens, 2016
Bacterial pathogens and their toxins target host receptors, leading to aberrant behavior or host death by changing signaling events through subversion of host intracellular cAMP level.
Ping Lin, Tingcai Cheng, Sanyuan Ma, Junping Gao, Shengkai Jin, Liang Jiang, Qingyou Xia   +6 more
doaj   +1 more source

High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. [PDF]

, 2017
Key pointsPatients with diabetes show a blunted cardiac inotropic response to β-adrenergic stimulation despite normal cardiac contractile reserve. Acute insulin stimulation impairs β-adrenergically induced contractile function in isolated cardiomyocytes ...
Chiamvimonvat, Nipavan, Fu, Qin, Hu, Yuting, Kim, Sungjin, Li, Ning, Liu, Yongming, Wang, Qingtong, Xiang, Yang K, Xu, Bing   +8 more
core   +2 more sources

Vasoactivity of Rac GTPase, Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Inhibition of vasocontraction accounts for side effects in treating voiding symptoms in benign prostatic hyperplasia (BPH). We examined the vasoactivity of compounds previously showing inhibition of prostate smooth muscle contraction. Contractions of porcine renal interlobar and coronary arteries were induced by agonists or electric field ...
Guangyang Liu, Sheng Hu, Alexander Tamalunas, Oluwafemi Kale, Yajie Xu, Christian G. Stief, Martin Hennenberg   +6 more
wiley   +1 more source

Modulación de la estabilidad de la quinasa de receptores acoplados a proteínas G (GRK2) por la ligasa Mdm2: implicaciones fisiológicas en la migración y la proliferación celular [PDF]

, 2007
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular.
Salcedo de Haro, Alicia
core   +1 more source

The effect of G protein-coupled receptor kinase 2 (GRK2) on lactation and on proliferation of mammary epithelial cells from dairy cows [PDF]

Journal of Dairy Science, 2016
Milk protein is an important component of milk and a nutritional source for human consumption. To better understand the molecular events underlying synthesis of milk proteins, the global gene expression patterns in mammary glands of dairy cow with high-quality milk (>3% milk protein; >3.5% milk fat) and low-quality milk (
Hou, Xiaoming, Hu, Hongliu, Lin, Ye, Qu, Bo, Gao, Xuejun, Li, Qingzhang   +5 more
openaire   +2 more sources

Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol‐Induced Heart Failure

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Manuel Vicente, Aaron García‐Blázquez, Antonio Martínez‐Sielva, Jussep Salgado‐Almario, Joaquín Jordán, Beatriz Domingo, Juan Llopis   +6 more
wiley   +1 more source

G protein-coupled receptor kinase 2 inhibition improves erectile function through amelioration of endothelial dysfunction and oxidative stress in a rat model of type 2 diabetes

Asian Journal of Andrology, 2019
Type 2 diabetes mellitus (T2DM) is a common cause of erectile dysfunction (ED). It has been demonstrated that G protein-coupled receptor kinase 2 (GRK2) overexpression contributes to diabetic endothelial dysfunction and oxidative stress, which also ...
Zhi-Hua Wan, Yuan-Jie Zhang, Lin Chen, Yong-Lian Guo, Guo-Hao Li, Ding Wu, Yong Wang   +6 more
doaj   +1 more source

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms [PDF]

, 2014
β-Arrestin (βarr)-1 and β-arrestin-2 (βarrs) are universal G-protein-coupled receptor adapter proteins that negatively regulate cardiac β-adrenergic receptor (βAR) function via βAR desensitization and downregulation.
Bathgate Siryk, Ashley, Cannavo, Alessandro, Dabul, Samalia, DE LUCIA, CLAUDIO, Gao, Erhe, Koch, Walter J, LEOSCO, DARIO, Liccardo, Daniela, Lymperopoulos, Anastasios, Pandya, Krunal, RENGO, GIUSEPPE, Walklett, Karlee   +11 more
core   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source