Results 91 to 100 of about 37,211,421 (159)

Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K–AKT signaling in rheumatoid arthritis

Chinese Medical Journal
. Background:. G protein-coupled receptor kinase 2 (GRK2) could participate in the regulation of diverse cells via interacting with non-G-protein-coupled receptors.
Tingting Liu, Chao Jin, Jing Sun, Lina Zhu, Chun Wang, Feng Xiao, Xiaochang Liu, Liying Lv, Xiaoke Yang, Wenjing Zhou, Chao Tan, Xianli Wang, Wei Wei, Xiangxiang Pan   +13 more
doaj   +1 more source

Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction

Neuropsychiatric Disease and Treatment, 2016
Xiuqing Tian,1 Qing Wang,1 Rui Guo,2 Lingling Xu,3 Qin M Chen,4 Yinglong Hou1 1Department of Cardiology, Qianfoshan Hospital of Shandong University, Jinan City, 2Department of Physiology, Nanjing University of Chinese Medicine, Nanjing City, 3College of
Tian X, Wang Q, Guo R, Xu L, Chen Q, Hou Y   +5 more
doaj  

Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure.

, 2017
The hypothesis that paroxetine decreases morbidity and mortality in patients with heart failure (HF) is plausible but unproven. Basic research demonstrates that inhibition of G protein-coupled receptor kinase 2 (GRK2) both in vitro and in vivo in the ...
Lymperopoulos, Anastasios, Powell, Jonathan M, Borzak, Steven, Hennekens, Charles H, Ebin, Emanuel   +4 more
core   +1 more source

Regulation of metabotropic glutamate receptor subtype 7a by PDZ-domain protein PICK1 [PDF]

, 2007
Metabotropic glutamate receptor subtype 7 (mGluR7) belongs to the family of G-protein coupled receptors. mGluR7 is widely distributed in the brain and primarily localized at presynaptic terminals, where it is thought to regulate neurotransmitter release ...
Zhang, C., Zhang, Chuansheng
core  

Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons

iScience
Summary: Oxytocin plays critical roles in the brain as a neuromodulator, regulating social and other affective behavior. However, the regulatory mechanisms controlling oxytocin receptor (OXTR) signaling in neurons remain unexplored.
Kiran George, Hanh T.M. Hoang, Taryn Tibbs, Raghavendra Y. Nagaraja, Guangpu Li, Eva Troyano-Rodriguez, Mohiuddin Ahmad   +6 more
doaj   +1 more source

Die Funktion der Helix 8 für die Regulation des Bradykinin B2 Rezeptors [PDF]

, 2012
Upon activation the human bradykinin B2 receptor (B2R) acts as guanine nucleotide exchange factor for the G proteins Gq/11 and Gi. Thereafter, it gets phosphorylated by G protein-coupled receptor kinases (GRKs) and recruits beta-arrestins, which block ...
Feierler, Jens
core   +1 more source

Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction

Cell Death Discovery
Hypoxia, a condition characterized by a temporary lack of oxygen, causes mitochondrial damage, which in turn leads to endothelial dysfunction. G-protein-coupled receptor kinase 2 (GRK2) plays a key role in vascular homeostasis and remodeling, influencing
Cristina Gatto, Maria Rosaria Rusciano, Daniela Sorriento, Paola Di Pietro, Angela Carmelita Abate, Valeria Visco, Nicola Montone, Pasquale Mone, Daniele Di Napoli, Pierpaolo Chivasso, Vito Domenico Bruno, Vincenza Valerio, Paolo Poggio, Guido Iaccarino, Gaetano Santulli, Carmine Vecchione, Albino Carrizzo, Michele Ciccarelli   +17 more
doaj   +1 more source

Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease.

, 2007
Alterations in signal transduction pathway of G-protein-coupled receptors (GPCRs) have been found in the cerebrocortex and in the peripheral cultured tissues of patients with Alzheimer's disease (AD).
D. Leosco, L. Golino, F. Rengo, IACCARINO, Guido, W. J. Koch, E. Sanzari, C. Zincarelli, G. Rengo, V. Canonico, M. Marchese, F. Fortunato   +10 more
core   +1 more source

Protein recruitment to receptor tyrosine kinase-mediated early signalling complexes. [PDF]

, 2007
Receptor tyrosine kinase (RTK) signalling regulates the activation of numerous cellular processes in response to various external stimuli. Spatio-temporal regulation of protein recruitment to activated tyrosine kinase receptors is important for the ...
Schller, A.C.
core  

A systems and molecular analysis of G protein-mediated signalling [PDF]

The ability of cells to respond correctly to signals from their microenvironment is an essential prerequisite of life. Many external signals are detected through G protein-coupled receptor (GPCR) signalling pathways, which control all aspects of ...
Croft, Wayne D.
core