Results 101 to 110 of about 6,839 (207)

EFFETTI DELLA TERAPIA CON METOPROLOLO E SFINGOSINA 1 FOSFATO IN UN MODELLO SPERIMENTALE DI SCOMPENSO CARDIACO POST-ISCHEMICO [PDF]

, 2017
Un evento patologico chiave nello Scompenso Cardiaco (SC) è la disregolazione dei recettori β adrenergici cardiaci (βAR) conseguenza dell’iperattivazione da parte delle catecolammine.
D'Amico, Maria Loreta
core   +1 more source

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
Insulin resistance (IR) and obesity are important risk factors for non-alcoholic fatty liver disease (NAFLD). G protein-coupled receptor kinase 2 (GRK2) is involved in the development of IR and obesity in vivo. However, its possible contribution to NAFLD and/or non-alcoholic steatohepatitis (NASH) independently of its role on IR or fat mass accretion ...
Cruces-Sande, Marta, Vila-Bedmar, Rocío, Arcones, Alba C., González-Rodríguez, Águeda, Rada, Patricia, Gutiérrez-de-Juan, Virginia, Vargas-Castrillón, Javier, Iruzubieta, Paula, Sánchez-González, Cristina, Formentini, Laura, Crespo, Javier, García-Monzón, Carmelo, Martínez-Chantar, María Luz, Valverde, Ángela M., Mayor Jr., Federico, Murga, Cristina   +15 more
openaire   +3 more sources

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis

Scientific Reports, 2017
Despite the associations between diabetic complications and vascular endothelial dysfunction, a direct therapeutic method targeting endothelial dysfunction remains poorly characterized.
Kumiko Taguchi, Mari Hida, Mami Hasegawa, Haruka Narimatsu, Takayuki Matsumoto, Tsuneo Kobayashi   +5 more
doaj   +1 more source

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. [PDF]

, 2008
International audienceLeukocytes from individuals with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency, and bearing a wild-type CXCR4 ORF (WHIM(WT)) display impaired CXCR4 internalization and ...
Balabanian, Karl, Levoye, Angélique, Klemm, Lysiane, Lagane, Bernard, Hermine, Olivier, Harriague, Julie, Baleux, Françoise, Arenzana-Seisdedos, Fernando, Bachelerie, Françoise   +8 more
core   +3 more sources

Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2

Frontiers in Pharmacology, 2019
Hyperaldosteronism alters cardiac function, inducing adverse left ventricle (LV) remodeling either via increased fibrosis deposition, mitochondrial dysfunction, or both.
Alessandro Cannavo, Alessandro Cannavo, Federica Marzano, Andrea Elia, Daniela Liccardo, Leonardo Bencivenga, Giuseppina Gambino, Claudia Perna, Antonio Rapacciuolo, Antonio Cittadini, Nicola Ferrara, Nicola Ferrara, Nazareno Paolocci, Nazareno Paolocci, Walter J. Koch, Giuseppe Rengo, Giuseppe Rengo   +16 more
doaj   +1 more source

Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure

JACC: Basic to Translational Science
Summary: GRK2 is the most prominent G protein-coupled receptor kinase that is upregulated in heart failure (HF), and inhibiting GRK2 has improved cardiac function in mice.
Rajika Roy, PhD, Sarah M. Schumacher, PhD, Haley Christine Murphy, BS, Jessica Grondolsky, Thiele Osvaldt Rosales, PhD, J. Kurt Chuprun, PhD, Erhe Gao, MD, PhD, Huaqing Zhao, PhD, MS, Remus M. Berretta, BS, Alexander R.H. Hobby, PhD, Steven R. Houser, PhD, Larisa V. Avramova, PhD, John J.G. Tesmer, PhD, Walter J. Koch, PhD   +13 more
doaj   +1 more source

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2 [PDF]

, 2014
This is a pre-copyedited, author-produced pdf of an article accepted for publication in Journal of Molecular Cell Biology following peer review. The version of record Journal of Molecular Cell Biology 6.4 (2014) is available online at: http://dx.doi.org ...
Ana Ruiz-Gómez, Cristina Murga, Federico Mayor, Iria Nieto-Vázquez, Lucia Garcia-Guerra, Mar Ruiz-Gómez, Margarita Lorenzo, Marta Carrasco-Rando, Marta Cruces-Sande, Mercedes Martín, Rocío Vila-Bedmar, Sonia Fernández-Veledo   +11 more
core   +2 more sources

Considering the role of Murine double minute 2 in the cardiovascular system [PDF]

, 2019
The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53 ...
Lam, Brian, Roudier, Emile
core   +1 more source