Results 121 to 130 of about 6,839 (207)

Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K–AKT signaling in rheumatoid arthritis

Chinese Medical Journal
. Background:. G protein-coupled receptor kinase 2 (GRK2) could participate in the regulation of diverse cells via interacting with non-G-protein-coupled receptors.
Tingting Liu, Chao Jin, Jing Sun, Lina Zhu, Chun Wang, Feng Xiao, Xiaochang Liu, Liying Lv, Xiaoke Yang, Wenjing Zhou, Chao Tan, Xianli Wang, Wei Wei, Xiangxiang Pan   +13 more
doaj   +1 more source

Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction

Neuropsychiatric Disease and Treatment, 2016
Xiuqing Tian,1 Qing Wang,1 Rui Guo,2 Lingling Xu,3 Qin M Chen,4 Yinglong Hou1 1Department of Cardiology, Qianfoshan Hospital of Shandong University, Jinan City, 2Department of Physiology, Nanjing University of Chinese Medicine, Nanjing City, 3College of
Tian X, Wang Q, Guo R, Xu L, Chen Q, Hou Y   +5 more
doaj  

An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo. [PDF]

, 2009
Aldosterone produces a multitude of effects in vivo, including promotion of postmyocardial infarction adverse cardiac remodeling and heart failure progression.
Kim, Jihee, Koch, Walter J, Lymperopoulos, Anastasios, Rengo, Giuseppe, Soltys, Stephen, Zincarelli, Carmela   +5 more
core   +1 more source

Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons

iScience
Summary: Oxytocin plays critical roles in the brain as a neuromodulator, regulating social and other affective behavior. However, the regulatory mechanisms controlling oxytocin receptor (OXTR) signaling in neurons remain unexplored.
Kiran George, Hanh T.M. Hoang, Taryn Tibbs, Raghavendra Y. Nagaraja, Guangpu Li, Eva Troyano-Rodriguez, Mohiuddin Ahmad   +6 more
doaj   +1 more source

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2, GRK2

, 2011
Peer ...
García-Guerra, Lucía, Vila-Bedmar, Rocío, Fernández-Veledo, Sonia, Murga, Cristina, Mayor Jr., Federico, Lorenzo, Margarita, Nieto-Vázquez, Iria   +6 more
openaire   +1 more source

Role of G protein-coupled receptor kinase 2 (GRK2) in insulin resistance and obesity

, 2011
Prevalence of obesity has reached epidemic scope in industrialized countries and it currently stands as a risk factor for the development of common metabolic disorders as insulin resistance and T2D. Nowadays, GRK2 has been recognized as an integrative node regulating a variety of transduction pathways including the insulin signaling cascade.
Fernández-Veledo, Sonia, García-Guerra, Lucía, Nieto-Vázquez, Iria, Vila-Bedmar, Rocío, Murga, Cristina, Mayor Jr., Federico   +5 more
openaire   +1 more source

GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis

Acta Pharmaceutica Sinica B
Hyperplasia and migration of fibroblast-like synoviocytes (FLSs) are the key drivers in the pathogenesis of rheumatoid arthritis (RA) and joint destruction.
Paipai Guo, Ji Jiang, Rui Chu, Feng He, Mingli Ge, Ruhong Fang, Qiuyun Guan, Huijuan Cheng, Chunru Jiang, Tiantian Su, Zhenduo Zhu, Hao Liu, Wei Wei, Shihao Zhang, Qingtong Wang   +14 more
doaj   +1 more source

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility [PDF]

, 2012
Lafarga, Vanesa, Lucas, Elisa, Mayor, Federico, Murga, Cristina, Nogués, Laura, Penela, Petronila, Rivas, Verónica, Tapia, Olga, Vila Bedmar, Rocío   +8 more
core   +2 more sources

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. [PDF]

, 2011
Chen M, Chuprun JK, Ciccarelli M, Dorn GW 2nd, Gao E, Gold JI, Gumpert A, Iaccarino G, Koch WJ, Otis NJ, Peroutka RJ, RENGO, GIUSEPPE, TRIMARCO, BRUNO, Wei Z   +13 more
core   +1 more source

Adrenergic Receptors [PDF]

, 2016
D. Sorriento, E. Coscioni, G. Iaccarino, G. Santulli, M. Ciccarelli   +4 more
core   +1 more source