Results 111 to 120 of about 6,839 (207)

Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family

FEBS Open Bio, 2019
Homologous domains embedded in multidomain proteins of different domain architectures (DA) may exhibit subtle, but important, differences in their structure and function.
Nagarajan Naveenkumar, Ramanathan Sowdhamini, Narayanaswamy Srinivasan   +2 more
doaj   +1 more source

The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion [PDF]

, 2002
The rat cytomegalovirus (RCMV) R33 gene is conserved among all betaherpesviruses and encodes a protein (pR33) that shows sequence similarity with chemokine-binding G protein-coupled receptors (GPCRs). Previously, the physiological significance of the R33
Broers, J.L., Bruggeman, C.A., Casarosa, P, Gruijthuijsen, Y.K., Kaptein, S.J., Leurs, R., Smit, M.J., Vink, C.   +7 more
core   +3 more sources

The diverse roles of G protein-coupled receptor kinase 2 (GRK2): a focus on regulation of receptor tyrosine kinases (RTKs).

Receptors & Clinical Investigation, 2014
The G protein-coupled receptor (GPCR) kinases (GRKs) are a family of seven serine/threonine kinases that are recruited to and activated by almost all agonist-occupied GPCRs. Upon recruitment and activation, GRK2 inhibits G protein-dependent signaling downstream of GPCRs both directly, for example by sequestering activated G proteins, and indirectly, by
openaire   +1 more source

Lipid dependent interaction of protein phosphatase 2A‐A (PP2A‐A) and G protein‐coupled receptor kinase 2 (GRK2)

The FASEB Journal, 2011
PP2A is a hetero‐trimeric Ser/Thr protein phosphatase. The A‐subunit serves as a scaffold protein onto which the catalytic subunit‐C binds at the carboxyl end and the B‐subunit at the amino‐terminal region. Using yeast 2‐hybrid selection, we found that GRK2, a Ser/Thr kinase, also binds to the A‐subunit.
Tapan Som, Jeffry B Stock
openaire   +1 more source

Baicalin and ginsenoside Rb1 regulate the expression of adipocyte GRK2 and browning markers under lipid overload [PDF]

Exploration of Endocrine and Metabolic Diseases
Aim: Baicalin and ginsenoside Rb1 show the ability to promote adipocyte browning, but their effects, especially combined treatment, and the related mechanisms under pathological conditions are less known. The study investigated the regulation of browning
Zhuqi Wang, Jiayi Lao, Ziqing Wang, Honglei Zhang, Xinhong Shi, Kang Liu   +5 more
doaj   +1 more source

Cross-Desensitization and Cointernalization of H1 and H2 Histamine Receptors Reveal New Insights into Histamine Signal Integration [PDF]

, 2013
G-protein coupled receptor (GPCR) signaling does not result from sequential activation of a linear pathway of proteins/enzymes, but rather from complex interactions of multiple, branched signaling routes, ie, signaling networks.
Alonso, Maria Natalia, Baldi, Alberto, Davio, Carlos Alberto, Fernández, Natalia Brenda, Gutkind, J. Silvio, Monczor, Federico, Notcovich, Cintia Karina, Shayo, Carina Claudia, Simaan, May   +8 more
core   +2 more sources

The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function. [PDF]

, 2014
The G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated GPCRs at the plasma membrane (PM). Here GRK5/GRK4 chimeras and point mutations in GRK5 identify a short sequence within the regulator of G protein signaling (RGS) domain in GRK5
Fischer, Christopher C., Jiang, Xiaoshan, Shen, Ke, Wedegaertner, Philip B, Xu, Hua   +4 more
core   +2 more sources

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Role of G‐protein coupled receptor kinase‐2 (GRK2) in the modulation of renal vascular response in SHR by PPAR

The FASEB Journal, 2008
G‐protein coupled receptor (GPCR) kinase‐2 (GRK‐2) has been impllicated in hypertension and GRK‐2 inhibition reduced blood pressure (BP). Peroxisome proliferators activated receptor γ (PPARγ), a transcription factor regulates GPCRs but the connection with GRK‐2 is not known. Here, we examined GRK‐2 role in PPARγ‐mediated improvement in SHR.
Zivar Yousefipour, Adebayo Oyekan, Mohammad Newaz   +2 more
openaire   +1 more source

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

Neurobiology of Disease, 2013
G protein-coupled receptor (GPCR) kinase 2 (GRK2) regulates cellular signaling via desensitization of GPCRs and by direct interaction with intracellular signaling molecules. We recently described that ischemic brain injury decreases cerebral GRK2 levels.
Cora H. Nijboer, Cobi J. Heijnen, Vincent Degos, Hanneke L.D.M. Willemen, Pierre Gressens, Annemieke Kavelaars   +5 more
doaj   +1 more source