Results 31 to 40 of about 37,211,421 (159)

Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations, which have great implications in hypertension. GRK2 (G protein‐coupled receptor kinase 2) is an essential regulator for many G protein‐coupled receptors and subsequent
Xuejing Sun, Mengli Zhou, Gaiyan Wen, Yun Huang, Junru Wu, Liping Peng, Weihong Jiang, Hong Yuan, Yao Lu, Jingjing Cai   +9 more
doaj   +1 more source

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

Frontiers in Pharmacology, 2023
The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction.
Viktor Burström, Richard Ågren, Nibal Betari, Marta Valle-León, Marta Valle-León, Emilio Garro-Martínez, Francisco Ciruela, Francisco Ciruela, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm   +11 more
doaj   +1 more source

Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion

Redox Biology, 2019
In sickle cell disease (SCD), recurrent painful vasoocclusive crisis are likely caused by repeated episodes of hypoxia and reoxygenation. The sickle erythrocyte (SSRBC) adhesion plays an active role in vasoocclusion.
Anson MacKinney, Emily Woska, Ivan Spasojevic, Ines Batinic-Haberle, Rahima Zennadi   +4 more
doaj   +1 more source

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Ladds, Graham, Thornton, Steven, Zervou, Sevasti I., Vatish, Manu, Davey, John   +4 more
core   +1 more source

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bas Vroling, Pin, J.-P., Palczewski, K., Camacho-Artacho, Marta, Pin, J.P., Lucy Skrabanek, Jean-Philippe Pin, Marta Camacho-Artacho, Devi, Lakshmi A, Graeme Milligan, Marta Filizola, Campagne, Fabien, Fabien Campagne, Martin J. Lohse, Jufang Shan, Lohse, Martin J, Vriend, Gerrit, Khelashvili, George, Milligan, Graeme, Camacho-Artacho, M., Skrabanek, L., George Khelashvili, Campagne, F., Susan R. George, Lakshmi A. Devi, Filizola, M., Pin, Jean-Philippe, Vroling, B., Bouvier, M., Devi, L.A., Richard R. Neubig, Marc Parmentier, George, Susan R, Palczewski, Krzysztof, Dorff, K., Shan, J., Vriend, G., Michel Bouvier, Lohse, M.J., Bouvier, Michel, Skrabanek, Lucy, Vroling, Bas, Filizola, Marta, Neubig, Richard R, Gerrit Vriend, Dorff, Kevin, Parmentier, Marc, Khelashvili, G., Javitch, J.A., Shan, Jufang, Parmentier, M., Javitch, Jonathan A, Krzysztof Palczewski, Kevin Dorff, Jonathan A. Javitch, George, S.R., Neubig, R.R., Milligan, G.   +57 more
core   +3 more sources

Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in clinical scenario 1

Scientific Reports, 2023
Clinical scenario 1 (CS1) is acute heart failure (HF) characterized by transient systolic blood pressure (SBP) elevation and pulmonary congestion. Although it is managed by vasodilators, the molecular mechanism remains unclear.
Hiroki Yano, Kenji Onoue, Shiho Tokinaga, Tomoko Ioka, Satomi Ishihara, Yukihiro Hashimoto, Yasuki Nakada, Hitoshi Nakagawa, Tomoya Ueda, Ayako Seno, Taku Nishida, Makoto Watanabe, Yoshihiko Saito   +12 more
doaj   +1 more source

GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis

Acta Pharmaceutica Sinica B
Rheumatoid arthritis (RA) is an autoimmune disease with a complex etiology. Monocyte-derived macrophages (MDMs) infiltration are associated with RA severity.
Xuezhi Yang, Yingjie Zhao, Qi Wei, Xuemin Zhu, Luping Wang, Wankang Zhang, Xiaoyi Liu, Jiajie Kuai, Fengling Wang, Wei Wei   +9 more
doaj   +1 more source

GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis

Pharmaceuticals, 2023
G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage ...
Jiawei Zhang, Xianzheng Zhang, Mingdian Lu, Yan Chang, Qingtong Wang, Jiajie Tu, Huaxun Wu, Chun Wang, Zhongyang Hong, Maoming Xiong, Lihua Song, Wei Wei   +11 more
doaj   +1 more source

Cell-Type Specific GRK2 Interactomes: Pathophysiological Implications [PDF]

, 2018
G protein-coupled receptor kinase 2 (GRK2) is emerging as a key hub in cell signaling cascades. In addition to modulating activated G protein-coupled receptors, GRK2 can phosphorylate and/or functionally interact with a complex network of cellular ...
Penela Márquez, Petronila, Nogués Vera, Laura, Reglero Gómez, Clara, Mayor Menéndez, Federico, Vila Bedmar, Rocio, Murga Montesinos, Cristina, Lucas, Elisa, Cruces Sande, Marta, Rivas Guerrero, Verónica   +8 more
core   +1 more source

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4) [PDF]

, 2012
Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh
Robben, Joris, Cooke, Alexandra, Gould, Gwyn W., McIntosh, Kathryn A., Gould, Gwyn, Milligan, Graeme, Cunningham, Margaret Rose, Pediani, John D., Cooke, Alexandra E., McIntosh, Kathryn, Nilsson, Mary, Mundell, Stuart, Plevin, Robin, Cunningham, Margaret R., McIntosh, Kathryn A, Pediani, John D, Gould, Gwyn W, Pediani, John, Nilsson, Mary Francis, Cunningham, Margaret R, Cooke, Alexandra E   +20 more
core   +4 more sources