G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. [PDF]
PLoS ONE, 2017 The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various ...
Philipp Schlegel +12 more
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G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub. [PDF]
Cell Mol Life Sci, 2019 Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an
Penela P +3 more
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Mechanisms of adrenocorticotropin-induced activation of erk 1/2 map kinase in the human H295R adrenal cell line [PDF]
, 2008 PhDThe role of ACTH in stimulating or inhibiting growth of adrenal cells has been a subject of some controversy. Reports that ACTH may stimulate Erk/MAP kinase in Y1 cells have suggested a role for cAMP in this process.
Janes, Mandy Elaine
core +4 more sources
Desensitization and internalization of endothelin receptor A: impact of G protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation. [PDF]
J Biol Chem, 2013 Gaertner F, Seidel T, Schulz U, Gummert J, Milting H. Desensitization and Internalization of Endothelin Receptor A IMPACT OF G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2)-MEDIATED PHOSPHORYLATION. Journal of Biological Chemistry.
Gärtner F +4 more
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eLife, 2021 G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser +6 more
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Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling
Pharmacology Research & Perspectives, 2022 G protein‐coupled receptors kinase 2 (GRK2) plays a major role in receptor regulation and, as a consequence, in cell biology and physiology. GRK2‐mediated receptor desensitization is performed by its kinase domain, which exerts receptor phosphorylation ...
Emiliana Echeverría +5 more
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Canonical and Non-Canonical Roles of GRK2 in Lymphocytes
Cells, 2021 G protein-coupled receptor kinase 2 (GRK2) is emerging as a key integrative signaling node in a variety of biological processes ranging from cell growth and proliferation to migration and chemotaxis.
Jing Cheng +2 more
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GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo
BMC Biology, 2021 Background Insulin secretion from the pancreatic β-cell is finely modulated by different signals to allow an adequate control of glucose homeostasis.
Alba C. Arcones +8 more
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Cells, 2021 The timing of centrosome separation and the distance moved apart influence the formation of the bipolar spindle, affecting chromosome stability. Epidermal growth factor receptor (EGFR) signaling induces early centrosome separation through downstream G ...
Clara Reglero +4 more
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Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells. [PDF]
PLoS ONE, 2013 G protein-coupled receptor 3 (GPR3) is a constitutively active receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels required for meiotic arrest in oocytes and CNS function.
Katie M Lowther +4 more
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