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GRK2 and Mitochondrial Dynamics in Cardiovascular Health and Disease. [PDF]
Int J Mol SciG protein-coupled receptors (GPCRs) represent a family of membrane proteins that regulate several cellular processes. Among the GPCRs, G protein-coupled receptor kinases (GRKs) regulate downstream signaling pathways and receptor desensitization. GRK2 has gained significant interest due to its cardiovascular physiology and pathological involvement. GRK2’
Gatto C +3 more
europepmc +4 more sources
The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions [PDF]
Cells, 2021 Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases ...
Daniela Sorriento +7 more
openaire +5 more sources
Frontiers in Medicine, 2019 Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e.,
Stefan Wolf +3 more
doaj +1 more source
Semicontinuity of the Automorphism Groups of Domains with Rough Boundary [PDF]
, 2012 Based on some ideas of Greene and Krantz, we study the semicontinuity of automorphism groups of domains in one and several complex variables. We show that semicontinuity fails for domains in $\CC^n$, $n > 1$, with Lipschitz boundary, but it holds for ...
Krantz, Steven G.
core +3 more sources
A novel GRK2/HDAC6 interaction modulates cell spreading and motility [PDF]
, 2011 Cell motility and adhesion involves dynamic microtubule (MT) acetylation/deacetylation, a process regulated by enzymes as HDAC6, a major cytoplasmic α-tubulin deacetylase.
Aymerich, Ivette +4 more
core +2 more sources
G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.
PLoS ONE, 2017 The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various ...
Philipp Schlegel +12 more
doaj +1 more source
The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility [PDF]
, 2012 G protein-coupled receptor kinase 2 (GRK2) is emerging as a key integrative node in cell migration control. In addition to its canonical role in the desensitization of G protein-coupled receptors involved in chemotaxis, novel recently identified GRK2 ...
Lafarga, Vanesa +2 more
core +2 more sources
The FASEB Journal, 2010 G protein‐coupled receptor (GPCR) kinases (GRKs) were identified by their ability to phosphorylate activated GPCRs. They constitute a branch of the AGC kinase superfamily and are activated by hormone‐treated receptors. Their mechanism of activation is largely unknown; thus, we initiated a study to identify GRK2
Rachel Sterne‐Marr +5 more
openaire +1 more source
Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns [PDF]
, 2016 © 2014 Elsevier B.V. G protein-coupled receptor kinase 2 (GRK2) has recently emerged as a negative modulator of insulin signaling. GRK2 downregulation improves insulin sensitivity and prevents systemic insulin resistance.
Jurado-Pueyo, María +4 more
core +1 more source
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2 [PDF]
, 2013 Tumor vessel dysfunction is a pivotal event in cancer progression. Using an in vivo neovascularization model, we identified G protein–coupled receptor kinase 2 (GRK2) as a key angiogenesis regulator.
Belperio +19 more
core +2 more sources