Results 11 to 20 of about 6,551 (208)
Canonical and Non-Canonical Roles of GRK2 in Lymphocytes [PDF]
Cells, 2021 G protein-coupled receptor kinase 2 (GRK2) is emerging as a key integrative signaling node in a variety of biological processes ranging from cell growth and proliferation to migration and chemotaxis.
Jing Cheng +2 more
doaj +6 more sources
Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization [PDF]
Translational medicine @ UniSa, 2014 G protein coupled receptor kinase 2 (GRK2) has a key role in cellular function by regulating different intracellular mechanisms in a kinase dependent or independent manner.
Sorriento, D +9 more
core +9 more sources
GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo [PDF]
BMC Biology, 2021 Background Insulin secretion from the pancreatic β-cell is finely modulated by different signals to allow an adequate control of glucose homeostasis.
Alba C. Arcones +8 more
doaj +2 more sources
, 2012 G protein coupled receptor kinases (GRKs) regulate the termination of G protein-coupled receptor (GPCR) activation by phosphorylating agonist-occupied GPCRs. Apart from terminating GPCR activation, more evidence emerges in recent years demonstrating that
Wang, Huijing
core +3 more sources
GRK2 deficiency is a pain [PDF]
, 2007 G protein-coupled receptor (GPCR) kinase (GRK)2 regulates the responsiveness of many GPCRS, e.g. CCR1, CCR2, CCR5, neurokinin-1 receptor, and metabotropic glutamate receptors, which are involved in the development of allodynia (pain due to a stimulus ...
Kleibeuker, W.
core +3 more sources
Cardiac GRK2 Protein Levels Show Sexual Dimorphism during Aging and Are Regulated by Ovarian Hormones [PDF]
Cells, 2021 Cardiovascular disease (CVD) risk shows a clear sexual dimorphism with age, with a lower incidence in young women compared to age-matched men. However, this protection is lost after menopause. We demonstrate that sex-biased sensitivity to the development
Alba C. Arcones +7 more
doaj +2 more sources
GRK2 Is a Novel Modulator of the MALT1 Oncoprotein
Blood, 2016 Background and Significance: Lymphocyte antigen receptor-dependent stimulation of the NF-κB transcription factor is a key event during the normal adaptive immune response. However, dysregulated activation of these signaling pathways can lead to lymphoma.
Thome, Margot +10 more
core +3 more sources
GRK2 and Mitochondrial Dynamics in Cardiovascular Health and Disease
International Journal of Molecular SciencesG protein-coupled receptors (GPCRs) represent a family of membrane proteins that regulate several cellular processes. Among the GPCRs, G protein-coupled receptor kinases (GRKs) regulate downstream signaling pathways and receptor desensitization. GRK2 has
Valeria Visco +3 more
core +4 more sources
GRK2 as a therapeutic target for heart failure
Expert Opinion on Therapeutic Targets, 2017 G protein-coupled receptor (GPCR) kinase-2 (GRK2) is a regulator of GPCRs, in particular β-adrenergic receptors (ARs), and as demonstrated by decades of investigation, it has a pivotal role in the development and progression of cardiovascular disease ...
D’amico, Maria Loreta +15 more
core +5 more sources
Recent advances in the development of GRK2 inhibitors: blocking the interaction of GRK2 with its partners. [PDF]
Acta Pharmacol SinHan CC +9 more
europepmc +2 more sources