Results 41 to 50 of about 6,551 (208)

GRK2: putting the brakes on the circadian clock

Receptors & Clinical Investigation, 2016
G protein-coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases that terminate G protein-coupled receptor (GPCR) signaling by phosphorylating the receptor and inducing its internalization. In addition to their canonical function, some GRKs can phosphorylate non-GPCR substrates and regulate GPCR signaling in a kinase ...
Lucia, Mendoza-Viveros, Arthur H, Cheng, Hai-Ying M, Cheng   +2 more
openaire   +2 more sources

GRK2 activates TRAF2–NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis

Acta Pharmaceutica Sinica B
G protein-coupled receptor kinase 2 (GRK2) participates in the phosphorylation and desensitization of G protein-coupled receptor (GPCR), impacting various biological processes such as inflammation and cell proliferation.
Chenchen Han, Liping Jiang, Weikang Wang, Shujun Zuo, Jintao Gu, Luying Chen, Zhuo Chen, Jiajie Kuai, Xuezhi Yang, Liang Xu, Yang Ma, Wei Wei   +11 more
doaj   +1 more source

Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis

Scientific Reports, 2017
Despite the associations between diabetic complications and vascular endothelial dysfunction, a direct therapeutic method targeting endothelial dysfunction remains poorly characterized.
Kumiko Taguchi, Mari Hida, Mami Hasegawa, Haruka Narimatsu, Takayuki Matsumoto, Tsuneo Kobayashi   +5 more
doaj   +1 more source

Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor

Frontiers in Pharmacology, 2018
Background: We recently identified the balance between the level of G protein coupled receptor kinase 2 (GRK2) and Epac1 in nociceptors as a key factor in the transition from acute to chronic pain that occurs in mice ‘primed’ by an inflammatory stimulus.
Hui-Jing Wang, Hui-Jing Wang, Han-Xin Gu, Niels Eijkelkamp, Cobi J. Heijnen, Annemieke Kavelaars   +5 more
doaj   +1 more source

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

ESC Heart Failure, 2020
Aims The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes ...
Michele Ciccarelli, Daniela Sorriento, Antonella Fiordelisi, Jessica Gambardella, Antonietta Franco, Carmine delGiudice, Marina Sala, Maria Gaia Monti, Alessia Bertamino, Pietro Campiglia, Marco Oliveti, Paolo Poggio, Giovanna Trinchese, Gina Cavaliere, Ersilia Cipolletta, Maria Pina Mollica, Domenico Bonaduce, Bruno Trimarco, Guido Iaccarino   +18 more
doaj   +1 more source

A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling. [PDF]

PLoS Pathogens, 2015
Kaposi's sarcoma (KS) is a highly disseminated angiogenic tumor of endothelial cells linked to infection by Kaposi's sarcoma-associated herpesvirus (KSHV).
Minmin Hu, Cong Wang, Wan Li, Weiping Lu, Zhiqiang Bai, Di Qin, Qin Yan, Jianzhong Zhu, Brian J Krueger, Rolf Renne, Shou-Jiang Gao, Chun Lu   +11 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Interaction between the Conserved Region in the C-terminal Domain of GRK2 and Rhodopsin Is Necessary for GRK2 to Catalyze Receptor Phosphorylation [PDF]

Journal of Biological Chemistry, 2000
The C-terminal domain of G protein-coupled receptor kinases (GRKs) consists of a conserved region and a variable region, and the variable region has been shown to direct the membrane translocation of cytosolic enzymes. The present work has revealed that the C-terminal domain may also be involved in kinase-receptor interaction that is primarily mediated
X Q, Gan, J Y, Wang, Q H, Yang, Z, Li, F, Liu, G, Pei, L, Li   +6 more
openaire   +2 more sources

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

Frontiers in Pharmacology, 2020
G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein ...
Emiliana Echeverría, Emiliana Echeverría, Maia Cabrera, Maia Cabrera, Valeria Burghi, Valeria Burghi, Máximo Sosa, Máximo Sosa, Sonia Ripoll, Sonia Ripoll, Agustín Yaneff, Agustín Yaneff, Federico Monczor, Federico Monczor, Carlos Davio, Carlos Davio, Carina Shayo, Natalia Fernández, Natalia Fernández   +18 more
doaj   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source