Results 21 to 30 of about 6,551 (208)
GRK2 Regulates ADP Signaling in Platelets Via P2Y1 and P2Y12. [PDF]
, 2022 The critical role of G protein-coupled receptor kinase 2 (GRK2) in regulating cardiac function has been well documented for \u3e3 decades. Targeting GRK2 has therefore been extensively studied as a novel approach to treating cardiovascular disease ...
Zhao, Xuefei +11 more
core +2 more sources
Circulation Research, 2016 Heart failure (HF) has been described as the inability of the myocardium to deliver oxygen and nutrients to a degree commensurate with the metabolic requirements of the body.1 Myocardial dysfunction induces compensatory neurohumoral mechanisms, including the sympathetic nervous system (SNS), as an attempt to preserve contractile performance.
Joshua G, Travers +2 more
openaire +2 more sources
Pharmaceuticals, 2023 G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage ...
Jiawei Zhang +11 more
doaj +1 more source
Biological Research, 2022 Background G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management.
Yu Chen +7 more
doaj +1 more source
GRK2 in the Heart: A GPCR Kinase and Beyond [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Heart failure (HF) is a common end point for many underlying cardiovascular diseases. Down-regulation and desensitization of β-adrenergic receptors (β-AR) caused by G-protein-coupled receptor (GPCR) kinase 2 (GRK2) are prominent features of HF.
Zheng Maggie, Huang +3 more
openaire +2 more sources
The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart
Cells, 2022 The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the RAF1-MAPK (mitogen-activated protein kinase) pathway, RKIP acts as a beneficial tumour suppressor.
Joshua Abd Alla, Ursula Quitterer
doaj +1 more source
Influence of GRK2 levels in hepatic pathophysiology [PDF]
, 2021 Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 27-04-2018Esta tesis tiene embargado el acceso al texto completo hasta el 27-04-2021G protein-coupled receptor ...
Cruces Sande, Marta
core +1 more source
Characterization of the GRK2 Binding Site of Gαq [PDF]
Journal of Biological Chemistry, 2004 Heterotrimeric guanine nucleotide-binding proteins (G proteins) transmit signals from membrane bound G protein-coupled receptors (GPCRs) to intracellular effector proteins. The G(q) subfamily of Galpha subunits couples GPCR activation to the enzymatic activity of phospholipase C-beta (PLC-beta).
Peter W, Day +5 more
openaire +2 more sources
Frontiers in Allergy, 2021 G protein-coupled receptor kinase 2 (GRK2) is an adapter protein that modulates G protein-coupled receptor (GPCR) signaling. It also regulates the functions and activity of other intracellular proteins in many cell types.
Ananth K. Kammala +4 more
doaj +1 more source
Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling
Pharmacology Research & Perspectives, 2022 G protein‐coupled receptors kinase 2 (GRK2) plays a major role in receptor regulation and, as a consequence, in cell biology and physiology. GRK2‐mediated receptor desensitization is performed by its kinase domain, which exerts receptor phosphorylation ...
Emiliana Echeverría +5 more
doaj +1 more source