Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6
Scientific Reports, 2017 Cyclooxygenase-2 catalyses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol.
Antje Brüser +9 more
doaj +1 more source
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. [PDF]
, 2003 G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation.
Barnhill, Jennifer F +5 more
core
Targeted elimination of G proteins and arrestins defines their specific contributions to both intensity and duration of G protein-coupled receptor signalling [PDF]
, 2016 G protein-coupled receptors (GPCRs) can initiate intracellular signalling cascades by coupling to an array of heterotrimeric G proteins and arrestin adaptor proteins. Understanding the contribution of each of these coupling options to GPCR signalling has
Alvarez-Curto, Elisa +6 more
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GIT2 deficiency attenuates concanavalin A‐induced hepatitis in mice
FEBS Open Bio, 2015 G protein‐coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein‐coupled receptors (GPCRs). The short‐splice form of GIT2 is expressed in peripheral
Yu-E Hao +10 more
doaj +1 more source
Gαq and its \u3ci\u3eAkt\u3c/i\u3eions [PDF]
, 2006 No abstract ...
Eckhart, Andrea D. +2 more
core +1 more source
Endocannabinoid system and anticancer properties of cannabinoids [PDF]
, 2016 Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).
Nowak, Agnieszka +3 more
core +2 more sources
SDF-1 and PDGF enhance [alpha]v[beta]5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines [PDF]
, 2009 CD23 acts through the [alpha]v[beta]5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. [alpha]v[beta]5 is expressed on normal B-cell precursors in the bone marrow.
Acharya, M. +3 more
core +2 more sources
GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart
Frontiers in Pharmacology, 2019 Mitochondrial regulation of energy production, calcium homeostasis, and cell death are critical for cardiac function. Accordingly, the structural and functional abnormalities of these organelles (mitochondrial dysfunction) contribute to developing ...
Daniela Sorriento +4 more
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The G-Protein-Coupled Receptor Kinase 2 Orchestrates Hair Follicle Homeostasis
Journal of Investigative DermatologyTightly regulated cell-cell and cell-niche intercommunications through intertwined signaling networks are involved in maintaining normal hair follicle (HF) homeostasis, cycling, and cell fate determination. However, knowledge of specific mechanisms through which hair loss takes place under pathological situations is needed.
Alejandro, Asensio +8 more
openaire +2 more sources
GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity
Cell Reports, 2016 Opioids remain the standard for analgesic care; however, adverse effects of systemic treatments contraindicate long-term administration. While most clinical opioids target mu opioid receptors (MOR), those that target the delta class (DOR) also ...
Allison Doyle Brackley +4 more
doaj +1 more source