Results 201 to 210 of about 377,426 (261)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors. [PDF]

Nat Commun
Nepveu-Traversy ME, Hassanzadeh M, Bruneau-Cossette L, Besserer-Offroy É, Brouillette R, Morissette S, Traboulsi H, Kirby K, Murza A, Longpré JM, Breton B, Gendron FP, Gaudreau S, Boudreault PL, Sarret P.   +14 more
europepmc   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Fabio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders. [PDF]

J Med Chem
Essa K, Ortiz Zacarías NV, Roth S, Xin BT, de Winter S, van der Horst C, Bleijs B, de Heiden RA, Voulgaraki R, Neubert E, Ovaa H, Danen EHJ, Mulder MPC, Moreau K, van der Es D, Heitman LH.   +15 more
europepmc   +1 more source

G-protein coupled receptors in metabolic reprogramming and cancer. [PDF]

Pharmacol Ther
Ahn S, Kaipparettu BA.
europepmc   +1 more source

Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling. [PDF]

PLoS Biol
Sachdev S, Roy S, Cheloha RW.
europepmc   +1 more source

Two G protein-coupled receptors bind ceramides in atherosclerosis progression: targets for a new therapeutic strategy. [PDF]

Signal Transduct Target Ther
Han Y, Illes P, Tang Y.
europepmc   +1 more source

Unraveling allosteric signaling of G protein-coupled receptors (GPCRs) by single-molecule fluorescence. [PDF]

Biophys Rev
Agbadaola MT, Hilger D, Keller S, Krainer G.   +3 more
europepmc   +1 more source

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This is not a G protein-coupled receptor

Trends in Pharmacological Sciences, 1993
On his canvas entitled 'La trahison des Images' ('The Perfidy of Images'), René Magritte painted a tobacco pipe in a very realistic manner and added the words: 'Ceci n'est pas une pipe' ('This is not a pipe'). In similar style, it is of prime importance to state that the first three-dimensional (3D) models of G protein-coupled receptors (GPCRs) that ...
M F, Hibert, S, Trumpp-Kallmeyer, J, Hoflack, A, Bruinvels   +3 more
openaire   +2 more sources