Results 21 to 30 of about 21,743,586 (235)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Further new results on strong resolving partitions for graphs
Open Mathematics, 2020 A set W of vertices of a connected graph G strongly resolves two different vertices x, y ∉ W if either d G(x, W) = d G(x, y) + d G(y, W) or d G(y, W) = d G(y, x) + d
Kuziak Dorota, Yero Ismael G.
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Divinización del mercado, teodicea liberal una respuesta no eurocéntrica
Ideas y Valores, 2018 Se examinan los supuestos del liberalismo económico (en sus versiones más puras y extremas), a través de los cuales este divinizó el mercado y lo convirtió en una instancia totalizadora exenta de toda crítica.
Jorge Polo Blanco
doaj +5 more sources
Brainstem Influence on Thalamocortical Oscillations during Anesthesia Emergence
Frontiers in Systems Neuroscience, 2017 Theories of mechanisms that impair or prevent consciousness during anesthesia that are related to thalamocortical oscillations have been proposed. Many methods of EEG analysis have been proposed as measures of anesthetic effects but only a few have ...
Christopher M. Scheib
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source