Results 61 to 70 of about 21,743,586 (235)

PD-L1 expression with immune-infiltrate evaluation and outcome prediction in melanoma patients treated with ipilimumab

OncoImmunology, 2018
Background: Tumor microenvironment may have a key role in providing immunological markers that can help predict clinical response to treatment with checkpoint inhibitors.
Gabriele Madonna, Carmen Ballesteros-Merino, Zipei Feng, Carlo Bifulco, Mariaelena Capone, Diana Giannarelli, Domenico Mallardo, Ester Simeone, Antonio M. Grimaldi, Corrado Caracò, Gerardo Botti, Bernard A. Fox, Paolo A. Ascierto   +12 more
doaj   +1 more source

VOAs labelled by complex reflection groups and 4d SCFTs

Journal of High Energy Physics, 2019
We define and study a class of N $$ \mathcal{N} $$ = 2 vertex operator algebras W G $$ {\mathcal{W}}_{\mathrm{G}} $$ labelled by complex reflection groups.
Federico Bonetti, Carlo Meneghelli, Leonardo Rastelli   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

[Stammbuch G. F. W. Schultze] [PDF]

[STAMMBUCH G. F. W. SCHULTZE] [Stammbuch G. F. W. Schultze] ( - ) Cover ( - ) Besitzvermerk ( - ) Einträge Bl. 2 - 20 ( - ) Einträge Bl. 23 - 43 ( - ) Einträge Bl. 45 - 65 ( - ) Einträge Bl. 66 - 77v ( -
Schultze, G. F. W.
core  

¿Qué tan leibnizianos eran los “leibnizianos” Ch. Wolff y A. G. Baumgarten? Reflexiones acerca de la teoría de la armonía preestablecida

Ideas y Valores, 2014
Las filosofías de Wolff y Baumgarten han sido tradicionalmente evaluadas como una mera sistematización de las doctrinas de Leibniz, carente de toda originalidad.
Gaston Robert
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

[Gerald Myers, Robert Brashear, and G. W. Bailey]

, 1989
Photograph of Gerald Myers, Robert Brashear, and G. W. Bailey. The accompanying caption states: "L-R Coach Gerald Myers, Robert Brashear, A&S Golf Tourney Chairman, and G. W. Bailey, Actor.
Halperin, Ian.
core  

How Leibnizian Were the “Leibnizians” Ch. Wolff and A. G. Baumgarten? Reflections on the Theory of Preestablished Harmony

Ideas y Valores, 2014
The philosophies of Wolff and Baumgarten have been traditionally evaluated as mere systematizations of the doctrines of Leibniz, and, therefore, as lacking all originality.
Gaston Robert
doaj  

Uma oficina poética de lembranças

Aletria: Revista de Estudos de Literatura, 2014
No ano de 2001, foi publicado o último livro do já então célebre escritor alemão W. G. Sebald, Austerlitz. Marcado pela digressão, pelo tom melancólico, pelo emprego de remissões factuais e pelo uso de fotografias, o livro se caracteriza como um gênero ...
Douglas Valeriano Pompeu
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source