Results 221 to 230 of about 46,574,544 (297)

A MAP-SNARE interaction links cortical microtubules to the exocytic fusion machinery during auxin-dependent growth remodeling. [PDF]

Sci Adv
Deng J, Qin J, Wang P, Zhao X, Zhang X, Fu J, Mao T, Wang X.   +7 more
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Repurposing SKQ1 as a meropenem potentiator against NDM-1-producing <i>Escherichia coli</i>. [PDF]

Virulence
Li X, Zhang Z, Zhang Z, Liu D, Lu H, Lu W, Qian Y, Chen H, Wang C, Tan C.   +9 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Identification of a mechanical signaling pathway activating type 1 fimbriae via a ZraSR two-component system in neonatal meningitis-associated <i>Escherichia coli</i>. [PDF]

Virulence
Li X, Wang J, Li Z, Guo X, Wang Y, Chen X, Zheng Y, Zhang Q, Liu R, Sun X, Liu B, Sun H.   +11 more
europepmc   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Genetics, Not Weather, Informs Migration Behaviors in a Long-Distance Migrant Songbird. [PDF]

Ecol Evol
McGee KE, Travis SE, Strong AM, Perlut NG.   +3 more
europepmc   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Size-dependent activation of ammonia borane on copper clusters (Cu _<i>x</i> , <i>x</i> = 2-10): a DFT study of bonding, electronic structure, and hydrogen evolution. [PDF]

RSC Adv
Abdelrazek GM, Zaki AH, Sakr MAS, Taha M.   +3 more
europepmc   +1 more source

Intermediate report about the E x G interaction of 30 olive varieties found in the five different GBs.

D.5.1. Intermediate report about the E x G interaction of 30 olive varieties found in the five different GBs (Month: 28; Type: R; Dissemination Level: PU).This deliverable will reflect the preliminary achieved results with regard to T5.1: Evaluation and comparison of the phenology (budburst, flowering and ripening) of more than 30 varieties in five ...
openaire   +1 more source