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Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAA receptor and GABAergic neuron in corresponding nuclei.

Acta Biochimica et Biophysica Sinica, 2021
Propofol is the most commonly used intravenous anesthetic worldwide. It can induce loss of consciousness prior to the occurrence of severe respiratory suppression, which is also a pharmacodynamic feature of all general anesthetics.
Jun-Li Jiang   +11 more
semanticscholar   +1 more source

The long and short of GABAergic neurons

Current Opinion in Neurobiology, 2013
GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the adult brain. Studies on GABAergic cells have focused almost exclusively on local interneurons neglecting those inhibitory neurons projecting to different brain areas, the 'long-range GABAergic cells'.
Antonio, Caputi   +3 more
openaire   +2 more sources

Asynchronism in the neurogenesis of GABAergic and non-GABAergic neurons in the mouse hippocampus

Developmental Brain Research, 1986
The time course of the neurogenesis of cells showing glutamic acid decarboxylase (GAD) immunoreactivity has been analyzed in the dorsal hippocampus and area dentata of the mouse. The quantitative data indicate that gamma-aminobutyric acid (GABA)ergic cells are generated prenatally, and that their peaks of neurogenesis occur before the peaks of ...
Soriano, Edwin   +2 more
openaire   +3 more sources

Effect of diazepam on gabaergic cuneate neurons

Neuropharmacology, 1979
Abstract Diazepam may act as a γ-aminobutyric acid (GABA) agonist in the CNS, but the evidence is conflicting. This study done with iontophoresis demonstrated that diazepam inhibited the spontaneously firing neurons in the cuneate nucleus, also inhibited by GABA.
R L, Polzin, C D, Barnes
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GABAergic neurons in rat hippocampal culture

Developmental Brain Research, 1986
The experiments described here were designed to study biochemical and histological measures of gamma-aminobutyric acid (GABA) uptake and glutamic acid decarboxylase (GAD) in primary dissociated cell cultures prepared from 17-21-day fetal rat hippocampus.
D B, Hoch, R, Dingledine
openaire   +2 more sources

Behavioral consequences of GABAergic neuronal diversity

Current Opinion in Neurobiology, 2014
The majority of cellular diversity in the hippocampus and neocortex derives from a relatively small population of local inhibitory interneurons. Recent technological advances have facilitated the recording and manipulation of defined inhibitory cell classes in awake rodents, revealing new and surprising roles for these cells in local circuit function ...
Matthew, Lovett-Barron, Attila, Losonczy
openaire   +2 more sources

GABAergic Neurons

Scientific American, 1988
One tends to think of the nervous system in terms of chains of excitatory signals that tell neurons to fire. The signals that say "Don't fire" also have a major role. Inhibitory signals damp overall neural activity and also fine-tune the responses of particular circuits. The primary carrier of these signals is the inhibitory transmitter known as GABA.
openaire   +2 more sources

Development of the GABAergic and glutamatergic neurons of the lateral hypothalamus

Journal of Chemical Neuroanatomy, 2021
In the last few years we assist to an unexpected deluge of genomic data on hypothalamic development and structure. Perhaps most surprisingly, the Lateral Zone has received much attention too. The new information focuses first of all on transcriptional heterogeneity.
Zhou, Xunlei   +2 more
openaire   +4 more sources

Gabaergic transmission by POA neurons to orexin neurons

Sleep Medicine, 2013
Introduction Populations of neurons in the hypothalamic preoptic area (POA) fire rapidly during sleep, exhibiting sleep/waking state-dependent firing patterns that are the reciprocal of those observed in the arousal system. The majority of these preoptic_gsleep-active_h neurons contain the inhibitory neurotransmitter GABA. These neurons are thought to
Y. Saito   +5 more
openaire   +1 more source

GABAergic septohippocampal neurons contain parvalbumin

Brain Research, 1989
Septal axons were visualized in the hippocampus by anterograde transport of Phaseolus vulgaris leucoagglutinin (PHAL) injected into the medial septal region, which contains large numbers of parvalbumin (PV)-immunoreactive somata. A proportion of the PHAL-labelled afferents in the hippocampus were shown to be immunoreactive for PV by immunostaining ...
openaire   +2 more sources

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