Placement of leucine zipper motifs at the carboxyl terminus of HIV-1 protease significantly reduces virion production. [PDF]
PLoS ONE, 2012 Natural HIV-1 protease (PR) is homodimeric. Some researchers believe that interactions between HIV-1 Gag-Pol molecules trigger the activation of embedded PR (which mediates Gag and Gag-Pol cleavage), and that Gag-Pol assembly domains outside of PR may ...
Yen-Yu Pan +4 more
doaj +1 more source
Catholic Social Services, Inc. v. C.A.A.: Best Interests and Statutory Construction of the Indian Child Welfare Act [PDF]
, 1990 The concept of "proteoglycans" as discrete molecules surfaced some 40 years ago, out of previously muddled notions of the extracellular matrix. Core proteins were gradually recognized as molecular entities, distinct with regard to location, substitution ...
Nazarian, Douglas R.
core +2 more sources
The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization
Advanced Biology, EarlyView.This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates +7 more
wiley +1 more source
The binding of glycosaminoglycans to peptides : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
, 1994 The overall aim this study was to examine the possibility of using immobilised polypeptide chains to fractionate/separate Glycosaminoglycans (GAG's) from mixtures. Initially individual samples of three GAG classes (chondroitin sulphate, dermatan sulphate
Taylor, Grant John
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From DeWitt initial condition to Cosmological Quantum Entanglement
, 2015 A gravity-anti-gravity (GaG) odd linear dilaton action offers an eternal inflation evolution governed by the unified (cosmological constant plus radiation) equation of state $\rho-3P=4\Lambda$.
Davidson, Aharon, Ygael, Tomer
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Arterial pathology in canine mucopolysaccharidosis-I and response to therapy. [PDF]
, 2011 Mucopolysaccharidosis-I (MPS-I) is an inherited deficiency of α-L-iduronidase (IdU) that causes lysosomal accumulation of glycosaminoglycans (GAG) in a variety of parenchymal cell types and connective tissues.
Dickson, Patricia I +6 more
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Advanced Biology, EarlyView.In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins +2 more
wiley +1 more source
Investigating the role between glycosaminoglycan immobilization approach and protein affinity
Frontiers in Biomaterials Science, 2023 Glycosaminoglycans (GAGs) are linear polysaccharides commonly used to impart bioactivity into synthetic hydrogels through their broad electrostatic-based protein-binding capabilities.
Nicholas Cornell, Donald Griffin
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Protein stabilization explains the gag requirement for transformation of lymphoid cells by Abelson murine leukemia virus [PDF]
, 1985 The single protein encoded by Abelson murine leukemia virus is a fusion of sequence from the retroviral gag genes with the v-abl sequence. Deletion of most of the gag region from the transforming protein results in a virus capable of transforming ...
Baltimore, David +3 more
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Advanced Functional Materials, EarlyView.A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo +13 more
wiley +1 more source