Results 101 to 110 of about 210,924 (322)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Novacene: The coming age of hyperintelligence—James Lovelock’s vision of posthumanism

Zagadnienia Filozoficzne w Nauce, 2021
James Lovelock, who is famous for the Gaia hypothesis, has written a new book called Novacene: The Coming Age of Hyperintelligence. It is an extended argument about an impending new epoch on Earth called Novacene in which biological life as we know it ...
Roman Krzanowski
doaj  

Gaia: The Astrometry Revolution [PDF]

Proceedings of the International Astronomical Union, 2015
AbstractThe power of micro-arcsecond (μas) astrometry is about to be unleashed. ESA's Gaia mission, now headed towards the end of the first year of routine science operations, will soon fulfil its promise for revolutionary science in countless aspects of Galactic astronomy and astrophysics.
SOZZETTI, Alessandro, Bonavita, M., DESIDERA, Silvano, GRATTON, Raffaele, LATTANZI, Mario Gilberto   +4 more
openaire   +5 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Assessing the Contribution of Urban Freight Terminals in Last Mile Operations

Transport and Telecommunication, 2016
This paper introduces a multi-stakeholder multi-criteria evaluation framework, which can be used for the assessment of the last mile distribution performance of urban freight terminals.
Nathanail Eftihia, Gogas Michael, Adamos Giannis   +2 more
doaj   +1 more source

The Gaia sky: version 1.0 [PDF]

, 2017
In this contribution I provide a brief summary of the contents of Gaia DR1. This is followed by a discussion of studies in the literature that attempt to characterize the quality of the Tycho-Gaia Astrometric Solution parallaxes in Gaia DR1, and I point out a misconception about the handling of the known systematic errors in the Gaia DR1 parallaxes.
arxiv   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Identità e miti dell’autoctonia nella Grecia antica. La terra, i figli della terra

Reti Medievali Rivista, 2015
Al centro dei dibattiti su identità e autoctonia nella Grecia antica spesso è Gaia, la Terra, dea generatrice, ma anche «sede stabile di dèi e di uomini», e di qui, probabilmente, terra civica.
Marisa Tortorelli Ghidini
doaj   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source