Results 51 to 60 of about 202,711 (324)

Gaia broad band photometry

, 2010
The scientific community needs to be prepared to analyse the data from Gaia, one of the most ambitious ESA space missions, to be launched in 2012. The purpose of this paper is to provide data and tools in order to predict in advance how Gaia photometry ...
A. Mora, A. Vallenari, Alexander, Allard, Alvarez, Andersen, Bertelli, Bertelli, Bessell, Bessell, Bessell, Bessell, Bessell, Bohlin, Bohlin, Bono, C. Fabricius, C. Jordi, Cardelli, Cousins, Fagotto, Fagotto, Fitzpatrick, Fitzpatrick, Fluks, Fukugita, Girardi, Grebel, Grevesse, Gustafsson, H. Voss, Hauschildt, Iben, Iglesias, Ivezić, J. de Bruijne, J. Knude, J. M. Carrasco, Jordi, Katz, Kochukhov, Lejeune, Lejeune, M. Gebran, Marigo, Marigo, Megessier, Oke, Perryman, Perryman, Pietrinferni, Pietrinferni, R. Kohley, Salasnich, Shulyak, van Leeuwen, Westera, Wilkinson   +57 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Novacene: The coming age of hyperintelligence—James Lovelock’s vision of posthumanism

Zagadnienia Filozoficzne w Nauce, 2021
James Lovelock, who is famous for the Gaia hypothesis, has written a new book called Novacene: The Coming Age of Hyperintelligence. It is an extended argument about an impending new epoch on Earth called Novacene in which biological life as we know it ...
Roman Krzanowski
doaj  

Identità e miti dell’autoctonia nella Grecia antica. La terra, i figli della terra

Reti Medievali Rivista, 2015
Al centro dei dibattiti su identità e autoctonia nella Grecia antica spesso è Gaia, la Terra, dea generatrice, ma anche «sede stabile di dèi e di uomini», e di qui, probabilmente, terra civica.
Marisa Tortorelli Ghidini
doaj   +1 more source

Immune cells and preterm labour:do invariant NKT cells hold the key? [PDF]

, 2015
We have developed our original made-to-measure (M2M) algorithm, PRIMAL, with the aim of modelling the Galactic disc from upcoming Gaia data. From a Milky Way like N-body disc galaxy simulation, we have created mock Gaia data using M0III stars as tracers,
Rinaldi, S F, Rossi, A G, Saunders, Philippa, Norman, J E   +3 more
core   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Implementing the Gaia Astrometric Global Iterative Solution (AGIS) in Java

, 2011
This paper provides a description of the Java software framework which has been constructed to run the Astrometric Global Iterative Solution for the Gaia mission.
Hernandez, Jose, Hobbs, David, Lammers, Uwe, Lindegren, Lennart, O'Mullane, William   +4 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Star Classification Possibilities with the Gaia Spectrophotometers. III. The Classification Accuracy with Decontaminated BP/RP Spectra

Open Astronomy, 2011
A medium-band 12-color photometric system, based on the decontaminated Gaia BP/RP spectra, has been proposed in our Paper II. Here we analyze a possibility to apply some versions of this system for the determination of temperatures and gravities of stars
Straižys V., Lazauskaitė R.
doaj   +1 more source