Results 61 to 70 of about 59,243 (307)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Sci-GaIA Kick-off Meeting Group Photo
, 2015 This is a group photo taken during the Sci-GaIA Kick-off Meeting held at Brunel University London on the 12th of May ...
The Sci-GaIA Consortium
core +1 more source
Novacene: The coming age of hyperintelligence—James Lovelock’s vision of posthumanism
Zagadnienia Filozoficzne w Nauce, 2021 James Lovelock, who is famous for the Gaia hypothesis, has written a new book called Novacene: The Coming Age of Hyperintelligence. It is an extended argument about an impending new epoch on Earth called Novacene in which biological life as we know it ...
Roman Krzanowski
doaj
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Sci-GaIA Newsletter - Issue no. 2 - October 2015
, 2015 The Sci-GaIA Partnership is very pleased to bring to your attention the latest developments in the field of Africa-EU cooperation on e-Infrastructures. The Sci-GaIA project aims at creating a sustainable foundation of educational materials and procedures
The Sci-GaIA Consortium
core +1 more source
La géographie humaine d’Hydace
Gaia, 2020 Hydatius’ Chronicle allows us to set a human geography map focused on the periphery of 5th century Roman Empire. Despite the pretention to be universal, it shows a world shrunk to Iberian territories as parts of the greater Christian space.
Christian Stein
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Gaia benchmark stars and their twins in the Gaia‐ESO Survey [PDF]
Astronomische Nachrichten, 2016 AbstractThe Gaia benchmark stars are stars with very precise stellar parameters that cover a wide range in the HR diagram at various metallicities. They are meant to be good representative of typical FGK stars in the Milky Way. Currently, they are used by several spectroscopic surveys to validate and calibrate the methods that analyse the data.
openaire +2 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source