Results 81 to 90 of about 202,711 (324)

Orbital Parameter Determination for Wide Stellar Binary Systems in the Age of Gaia

, 2020
The orbits of binary stars and planets, particularly eccentricities and inclinations, encode the angular momentum within these systems. Within stellar multiple systems, the magnitude and (mis)alignment of angular momentum vectors among stars, disks, and ...
Dupuy, Trent J., Kraus, Adam L., Mann, Andrew W., Newton, Elisabeth R., Pearce, Logan A., Tofflemire, Benjamin N., Vanderburg, Andrew   +6 more
core   +1 more source

GaiaData Release 2 [PDF]

Astronomy & Astrophysics, 2018
Context.The secondGaiadata release (GaiaDR2) provides precise five-parameter astrometric data (positions, proper motions, and parallaxes) for an unprecedented number of sources (more than 1.3 billion, mostly stars). This new wealth of data will enable the undertaking of statistical analysis of many astrophysical problems that were previously infeasible
Luri, X., Brown, A., Sarro, L., Arenou, Frédéric, Bailer-Jones, C, Castro-Ginard, A., de Bruijne, J., Prusti, T., Babusiaux, C., Delgado, H.   +9 more
openaire   +7 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Avaliação do desenvolvimento psicomotor pelos médicos de família: estudo observacional

Revista Portuguesa de Medicina Geral e Familiar, 2016
Objetivos: Compreender a realidade da avaliação do desenvolvimento psicomotor no âmbito das consultas de vigilância de saúde infantil nas unidades de cuidados de saúde primários dos ACES Gaia e Espinho/Gaia.
Ana Rita Maia, João Fernandes, Mariana Fidalgo Leite, Helena Santos, Susana Aires Pereira   +4 more
doaj   +1 more source

Exoplanets with Gaia: Synergies in the Making

, 2014
The era of high-precision astrometry has dawned upon us. The potential of Gaia $\mu$as-level precision in positional measurements is about to be unleashed in the field of extrasolar planetary systems.
Sozzetti, A.
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Overall properties of the Gaia DR1 reference frame

, 2017
We compare quasar positions of the auxiliary quasar solution with ICRF2 sources using different samples and evaluate the influence on the {\it Gaia} DR1 reference frame owing to the Galactic aberration effect over the J2000.0-J20015.0 period.
Ding, C. -Y., Liu, J. -C., Liu, N., Zhu, Z.   +3 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source