Results 31 to 40 of about 176,071 (266)

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Gait analysis as a clinical tool for dementia: current perspectives and future challenges

Advances in Clinical Neuroscience & Rehabilitation, 2021
Gait, the way that we walk, requires complex cognitive functions. Gait may be a useful early marker for dementia diagnosis, as gait impairments precede and reflect cognitive decline.
Mc Ardle, Riona, Del Din, Silvia, Yarnall, Alison   +2 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Effects of lower extremity constraint-induced movement therapy on gait and balance of chronic hemiparetic patients after stroke: description of a study protocol for a randomized controlled clinical trial

Trials, 2021
Background Protocols involving intensive practice have shown positive outcomes. Constraint induced movement therapy (CIT) appears to be one of the best options for better outcomes in upper limb rehabilitation, but we still have little data about lower ...
Elaine Menezes-Oliveira, Gabriela da Silva Matuti, Clarissa Barros de Oliveira, Simone Ferreira de Freitas, Catia Miyuki Kawamura, José Augusto Fernandes Lopes, Ricardo Mario Arida   +6 more
doaj   +1 more source

The association between isometric strength and cognitive function in adults with cerebral palsy

Frontiers in Medicine, 2023
BackgroundThe literature supports quantifying the maximum force/tension generated by one’s forearm muscles such as the hand grip strength (HGS) to screen for physical and cognitive frailty in older adults.
Patricia C. Heyn, Patricia C. Heyn, Alex Tagawa, Alex Tagawa, Zhaoxing Pan, Zhaoxing Pan, Timothy Reistetter, Ted Kheng Siang Ng, Meredith Lewis, Meredith Lewis, James J. Carollo, James J. Carollo, James J. Carollo   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of Obesity on Knee and Ankle Biomechanics during Walking

Sensors, 2021
The purpose of this retrospective study was to quantify the three-dimensional knee and ankle joint kinematics and kinetics during walking in young participants with different degrees of obesity and to identify the associated effects by stratifying the ...
Paolo Capodaglio, Michele Gobbi, Lucia Donno, Andrea Fumagalli, Camillo Buratto, Manuela Galli, Veronica Cimolin   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Bone mineral density and hip migration index in children with spinal muscular atrophy: a cross-sectional analysis 2024–2026 – report [PDF]

Chirurgia Narządów Ruchu i Ortopedia Polska
Introduction. Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder in which primary motor neuron degeneration is accompanied by secondary skeletal complications, including impaired bone mineralisation and hip instability.
Marek Jóźwiak, Amadeusz Brzykcy, Sabina Brazevic, Magdalena Ratajczyk, Paweł Chmara, Patrycja Sakowska, Przemysław Daroszewski, Radosław Rutkowski   +7 more
doaj   +1 more source