Results 71 to 80 of about 1,727,719 (289)

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Beyond gait speed: exploring the added value of Inertial Measurement Unit-based measurements of gait in the estimation of the walking ability in daily life

BMC Neurology
Background Gait speed is often used to estimate the walking ability in daily life in people after stroke. While measuring gait with inertial measurement units (IMUs) during clinical assessment yields additional information, it remains unclear if this ...
R. A. W. Felius, N. C. Wouda, M. Geerars, S. M. Bruijn, J. H. van Dieën, M. Punt   +5 more
doaj   +1 more source

Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia

Journal of Orthopaedic Surgery, 2020
Purpose: The purpose of this study was to evaluate the implication of gait speed, which is a prerequisite for the diagnosis of sarcopenia in older patients with lumbar spinal stenosis (LSS).
Yoshihito Sakai, Norimitsu Wakao, Hiroki Matsui, Keisuke Tomita, Tsuyoshi Watanabe, Hiroki Iida   +5 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The sex difference in gait speed among older adults: how do sociodemographic, lifestyle, social and health determinants contribute?

BMC Geriatrics, 2021
Background This study explores whether a sex difference in sensitivity to (strength of the association) and/or in exposure to (prevalence) determinants of gait speed contributes to the observed lower gait speed among older women compared to men.
Lena D. Sialino, Laura A. Schaap, Sandra H. van Oostrom, H. Susan J. Picavet, Johannes W.R. Twisk, W. M. Monique Verschuren, Marjolein Visser, Hanneke A.H. Wijnhoven   +7 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

The Influence of Agility and Maximum Gait Speed on Gait Ability

Rigakuryoho Kagaku, 2005
上下肢の敏捷性が最大歩行速度に及ぼす影響について検討するため，健常若年者22名を対象とし，最大歩行速度，最大タッピング，最大ステッピング，握力，脚力を測定した。上肢の敏捷性の指標である最大タッピングと下肢の敏捷性の指標である最大ステッピングとの間には有意な相関は見られなかった。最大歩行速度と有意な相関を示した測定項目は最大ステッピングおよび脚力であった（p＜0.05）。重回帰分析を行った結果，最大歩行速度は最大ステッピングが有意な変数として採用された。上下肢の敏捷性には相関がなく，それぞれが独立していたことにより，敏捷性に関する能力は部位によって異なることが考えられる。したがって，敏捷性を評価するには上肢だけではなく，下肢についても考慮することが重要であると考えられる。最大ステッピングの速い人ほど ...
SAITO, Kotoko, MARUYAMA, Hitoshi
openaire   +2 more sources

Front-view Gait Recognition [PDF]

, 2008
We present a new method for front-view gait biometrics which uses a single non-calibrated camera and extracts unique signatures from descriptors of a silhouette’s deformation.
Mark S. Nixon, Goffredo, Michela, Michela Goffredo, Nixon, Mark S., John N. Carter, Carter, John N.   +5 more
core   +2 more sources

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source