Results 61 to 70 of about 6,069 (180)

The mechanism of Andrena camellia in digesting toxic sugars

iScience
Summary: Camellia oleifera is an economically and medicinally valuable oilseed crop. Honeybee, the most abundant pollinator, rarely visits C. oleifera because of the toxic sugars in the nectar and pollen.
Zhen Li, Shiqing Zhong, Qiang Huang, Yong Zhang, Tianyu Xu, Wenkai Shi, Dongsheng Guo, Zhijiang Zeng   +7 more
doaj   +1 more source

Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model

Disease Models & Mechanisms, 2014
Classic galactosemia (CG) is an autosomal recessive disorder resulting from loss of galactose-1-phosphate uridyltransferase (GALT), which catalyzes conversion of galactose-1-phosphate and uridine diphosphate (UDP)-glucose to glucose-1-phosphate and UDP ...
Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie   +2 more
doaj   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, Volume 15, Issue 8, Page 1336-1349, August 2025.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Assessing Cofactor Usage in Pseudoclostridium thermosuccinogenes via Heterologous Expression of Central Metabolic Enzymes

Frontiers in Microbiology, 2019
Pseudoclostridium thermosuccinogenes and Hungateiclostridium thermocellum are being studied for their potential to contribute to a more sustainable bio-based economy.
Jeroen Girwar Koendjbiharie, Kimberly Wevers, Richard van Kranenburg, Richard van Kranenburg   +3 more
doaj   +1 more source

Strengthen or Weaken: Evolutionary Directions of Cross‐Feeding After Formation

Environmental Microbiology Reports, Volume 17, Issue 4, August 2025.
There are two evolutionary directions for cross‐feeding consortia after formation: strengthening and weakening. Simultaneously, cross‐feeding reshapes the focal strain evolution from niche space, selective pressure, horizontal gene transfer, and evolutionary rate.
Laipeng Luo, Xiaoli Chen, Bingwen Liu, Yong Nie, Xiao‐Lei Wu   +4 more
wiley   +1 more source

Biosynthesis of GDP-fucose and other sugar nucleotides in the blood-stages of Plasmodium falciparum [PDF]

, 2013
Carbohydrate structures play important roles in many biological processes, including cell adhesion, cell-cell communication, and host-pathogen interactions. Sugar nucleotides are activated forms of sugars used by the cell as donors for most glycosylation
Bandini, Giulia, Bernabeu, Maria, Fernández Becerra, Carmen, Izquierdo, Luis, Mariño, Karina Valeria, Ospina, Diego, Sanz, Silvia   +6 more
core   +2 more sources

Galactan mobilization during carbon starvation compromises plant cell wall‐mediated resistance to fungal infection

The Plant Journal, Volume 123, Issue 4, August 2025.
Significance Statement Polysaccharides present in plant cell walls must be dynamically modified in response to external stimuli, but it is not well understood how cell wall remodeling is adjusted in response to metabolic cues and how this affects defense against pathogens.
Louisa Reckleben, Richard N. Morton, Kristina S. Munzert‐Eberlein, Sabine Thiel, Carsten Rautengarten, Viviana Tan, Klara L. Harres, Lena Zanoni, Berit Ebert, Timo Engelsdorf   +9 more
wiley   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, Volume 599, Issue 11, Page 1609-1621, June 2025.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses [PDF]

, 2013
The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model.
Aude-Garcia, Catherine, Carrière, Marie, Chevallet, Mireille, Collin-Faure, Véronique, Diemer, Hélène, Habert, Aurélie, Hanau, Daniel, Herlin-Boime, Nathalie, Proamer, Fabienne, Rabilloud, Thierry, Strub, Jean-Marc, Triboulet, Sarah, Van Dorsselaer, Alain   +12 more
core   +5 more sources

Results of the ACTION‐Galactosemia Kids Study to Evaluate the Effects of Govorestat in Pediatric Patients with Classic Galactosemia

The Journal of Clinical Pharmacology, Volume 65, Issue 5, Page 575-587, May 2025.
Abstract To evaluate the pharmacodynamic effects and clinical outcomes of orally administered once‐daily govorestat (AT‐007), a central nervous system penetrant aldose reductase inhibitor, the double‐blind placebo‐controlled ACTION‐Galactosemia Kids study (NCT04902781) randomly assigned 47 participants (2‐17 years old) with Classic Galactosemia to 18 ...
Evan Bailey, Han Phan, Ayesha Ahmad, Janet Thomas, Elizabeth G. Ames, Amanda B. Pritchard, Shane C. Quinonez, Stella Wang, Caleb Dayley, Andrew Salt, Christina Pick, Abe Durrant, Samuel Johnson, Jessie Nicodemus‐Johnson, Samuel P. Dickson, Riccardo Perfetti, Suzanne B. Hendrix, Shoshana Shendelman   +17 more
wiley   +1 more source