Results 41 to 50 of about 4,175 (247)

Quality of life in heart failure. The heart of the matter. A scientific statement of the Heart Failure Association and the European Association of Preventive Cardiology of the European Society of Cardiology

open access: yesEuropean Journal of Heart Failure, EarlyView.
For most patients with chronic, progressive illnesses, maintaining good quality of life (QoL), with preserved functional capacity, is just as crucial as prolonging survival. Patients with heart failure (HF) experience much worse QoL and effort intolerance than both the general population and people with other chronic conditions, since they present a ...
Maurizio Volterrani   +21 more
wiley   +1 more source

Hydrogen peroxide ‐ responsive aminoferrocene prodrugs

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
Aminoferrocene (AF)‐based prodrugs are activated in cancer cells through reactions with H₂O₂ and other reactive oxygen species (ROS), generating electron‐rich AF’s. These, in turn, induce the production of highly toxic O2·‐ and HO·, leading to cancer cell death.
Marlies Körber   +3 more
wiley   +1 more source

Tumor desialylation surpasses anti‐PD‐L1 checkpoint therapy in restoring anti‐tumor immunity in a murine model for colorectal cancer

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Our research highlights how tumor sialylation affects tumor growth and reshapes the immune tumor microenvironment in colorectal cancer. We demonstrate for the first time that complete removal of sialic acids from colorectal tumor cells elicits a robust anti‐tumor immune response, but does not enhance anti‐PD‐L1 blockade efficacy.
Irene van der Haar Àvila   +11 more
wiley   +1 more source

Gut microbiota and tuberculosis

open access: yesiMeta, EarlyView.
This review explores the intricate relationship between gut microbiota (GM) and tuberculosis (TB). The figure illustrates the bidirectional effects between GM dynamics and TB progression, as well as the interactions between the GM and antituberculosis drugs.
Yanhua Liu   +39 more
wiley   +1 more source

ATAC‐seq in Emerging Model Organisms: Challenges and Strategies

open access: yesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Principle of ATAC‐seq (left), overview of arthropod species with published ATAC‐seq data (middle), summary of experimental design (right). ABSTRACT The Assay for Transposase‐Accessible Chromatin with sequencing (ATAC‐seq) is a versatile and widely utilized method for identifying potential regulatory regions, such as promoters and enhancers, within a ...
Duğçar Ebrar Erdoğan   +13 more
wiley   +1 more source

The Nature of Quasars and the Active Nuclei of Galaxies [PDF]

open access: bronze, 1977
Виталий Л. Гинзбург   +1 more
openalex   +1 more source

Nuclear Activity in Nearby Galaxies [PDF]

open access: yesAnnual Review of Astronomy and Astrophysics, 2008
A significant fraction of nearby galaxies show evidence of weak nuclear activity unrelated to normal stellar processes. Recent high-resolution, multiwavelength observations indicate that the bulk of this activity derives from black hole accretion with a wide range of accretion rates.
openaire   +3 more sources

Diastereoselectivity in the Synthesis of m‐ and p‐Substituted 3‐Aryl‐2‐trichloromethyl‐1,3‐thiazolidin‐4‐one Sulfoxides With Oxone

open access: yesJournal of Heterocyclic Chemistry, EarlyView.
Highly selective oxidation of thiazolidin‐4‐ones to sulfoxides and sulfones with Oxone and KMnO4, respectively. ABSTRACT S‐Oxidation of 3‐Aryl‐2‐trichloromethyl‐1,3‐thiazolidin‐4‐ones with Oxone was investigated. For all compounds evaluated, selective oxidation to the sulfoxide versus the sulfone was realized using 3 equivalents of Oxone at room ...
Ahmed Y. Nuriye   +3 more
wiley   +1 more source

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