Results 221 to 230 of about 166,323 (379)

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).
Emanuela Pesce   +25 more
wiley   +1 more source

CTCF Is Essential for the Development and Maintenance of CALM‐AF10‐Induced Leukemia

open access: yesCancer Science, EarlyView.
CTCF regulates TGM2 gene expression by modulating key histone modifications, including increased acetylation of H3K27 (H3K27ac) and trimethylation of H3K4 (H3K4me3), along with decreased trimethylation of H3K27 (H3K27me3). These epigenetic changes are critical for maintaining the stem‐like properties of CALM‐AF10‐induced AML. Pharmacological inhibition
Yoko Kuroki   +5 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

open access: yesNature
Poulain M   +10 more
europepmc   +1 more source

Deep Learning for Detecting Dental Plaque and Gingivitis From Oral Photographs: A Systematic Review

open access: yesCommunity Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives This systematic review aimed to evaluate the performance of deep learning (DL) models in detecting dental plaque and gingivitis from red, green, and blue (RGB) intraoral photographs. Methods A comprehensive literature search was conducted across Medline, Scopus, Embase, and Web of Science databases up to January 31, 2025.
Mohammad Moharrami   +7 more
wiley   +1 more source

A giant disk galaxy two billion years after the Big Bang. [PDF]

open access: yesNat Astron
Wang W   +16 more
europepmc   +1 more source

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