Results 261 to 270 of about 12,900,459 (404)

Groups of galaxies [PDF]

open access: yesProceedings of Baryons in Dark Matter Halos — PoS(BDMH2004), 2004
openaire   +2 more sources

Characterization of Human Senescent Cell Biomarkers for Clinical Trials

open access: yesAging Cell, Volume 24, Issue 5, May 2025.
Assessment of T‐cell p16_variant 5 expression may be useful for selecting participants in clinical trials of senolytics. We further characterize p16_variant 5 expression in the context of senescence and demonstrate that correlated plasma senescence‐associated secretory phenotype factors could be used in lieu of the technically challenging T‐cell ...
Joshua N. Farr   +6 more
wiley   +1 more source

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

open access: yesAging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox   +13 more
wiley   +1 more source

Persistence of Ancestral KhoeSan Mitochondrial Patterns in Contemporary South African Populations

open access: yesAnnals of Human Genetics, EarlyView.
Abstract Introduction Southern Africa has been inhabited by hunter‐gatherers for at least 20,000 years and has received diverse immigration flows in the last 2000 years. The original inhabitants have interacted with the pastoralist migrants from Eastern Africa (∼2000 ybp), followed by the southern Bantu migration arriving some 1000 ybp, and more ...
Maria Eugenia D'Amato   +7 more
wiley   +1 more source

Has Politics Become More Professional? Career and Legislative Professionalisation in the Australian Parliament Since 1950

open access: yesAustralian Journal of Politics &History, EarlyView.
“Professional politicians” have been lamented for their perceived negative impact on representative democracy. However, the concept of “political professionalisation” is deployed inconsistently, making these claims difficult to assess. This article develops a framework to measure professionalisation across two dimensions: career professionalisation ...
Peter Ferguson   +3 more
wiley   +1 more source

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