Results 251 to 260 of about 51,657 (292)

Galectins and Neuroinflammation

2014
Galectins, β-galactoside-binding lectins, play multiple roles in the regulation of immune and inflammatory responses. The major galectins expressed in the CNS are galectins 1, 3, 4, 8, and 9. Under normal physiological conditions, galectins maintain CNS homeostasis by participating in neuronal myelination, neuronal stem cell proliferation, and apical ...
Hung-Lin, Chen, Fang, Liao, Teng-Nan, Lin, Fu-Tong, Liu   +3 more
openaire   +2 more sources

The interrelation of galectins and autophagy

International Immunopharmacology, 2023
Autophagy is a vital physiological process that maintains intracellular homeostasis by removing damaged organelles and senescent or misfolded molecules. However, excessive autophagy results in cell death and apoptosis, which will lead to a variety of diseases.
Lujuan Zheng, Jing Xia, Pengyu Ge, Yuhan Meng, Weili Li, Mingming Li, Min Wang, Chengcheng Song, Yuying Fan, Yifa Zhou   +9 more
openaire   +2 more sources

Galectin-3 and metastasis

Glycoconjugate Journal, 2002
Galectin-3, a 31 kDa member of the beta-galactoside-binding proteins, is an intracellular and extracellular lectin which interacts with intracellular glycoproteins, cell surface molecules and extracellular matrix proteins. Galectin-3 is expressed widely in epithelial and immune cells and its expression is correlated with cancer aggressiveness and ...
Yukinori Takenaka, Avraham Raz, Tomoharu Fukumori   +2 more
exaly   +3 more sources

Galectin-8: a complex sub-family of galectins (Review)

International Journal of Molecular Medicine, 2001
Galectins are animal lectins, that can specifically bind beta-galactosides. Twelve galectins have been described in vertebrates, belonging to three different groups: prototype, tandem-repeat and chimeric. These proteins seem to be involved in cellular interactions and neoplastic transformations.
N, Bidon, F, Brichory, P, Bourguet, J P, Le Pennec, L, Dazord   +4 more
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The Levels of Expression of Galectin‐3, But Not of Galectin‐1 and Galectin‐8, Correlate With Apoptosis in Human Cholesteatomas

The Laryngoscope, 2001
AbstractObjectives To investigate whether galectins 1, 3, and 8 are expressed in human cholesteatomas and whether any such expression does correlate with the level of apoptosis, which is, as we have previously shown, predictive of recurrence. 7Study Design The analysis of 52 cholesteatomas resected by the same surgeon by means of canal wall up and ...
Sheikholeslam-zadeh, R, Decaestecker, Christine, Delbrouck, Carine, Danguy, André, Salmon, Isabelle, Zick, Yehiel, Kaltner, Herbert, Hassid, Sergio, Gabius, Hans-Joachim, Kiss, Robert, Choufani, Georges   +10 more
openaire   +3 more sources

Inhibition and Detection of Galectins

ChemBioChem, 2006
AbstractMore and more studies report on the roles that galectins play in numerous types of cancer. These roles can be varied, as has been shown particularly for galectin‐3. These studies have created the need for inhibitors that can block unwanted effects, and the need to detect galectins in tissues, in order to better understand their role, and aid in
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Galectin-3 in cancer

Clinica Chimica Acta, 2014
Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-
Lin, Song, Jian-wu, Tang, Lawrence, Owusu, Ming-Zhong, Sun, Jun, Wu, Jun, Zhang   +5 more
openaire   +2 more sources

Galectins in Atherosclerotic Disease

Trends in Cardiovascular Medicine, 2009
Although cells constantly adapt to external humoral cues, like cytokines and hormones, in practice, most cellular behavior is under locally guided control, via cell-cell interactions. The most prominent members of this group of molecules involved in this intercellular signaling are the galectins, a family of carbohydrate-binding proteins, which by ...
Sali, Al-Ansari, Clark J, Zeebregts, Riemer H J A, Slart, Maikel, Peppelenbosch, René A, Tio   +4 more
openaire   +2 more sources

Galectins in Regulation of Apoptosis

2011
The term “galectins” was given in 1994 to a family of animal lectins that bind to β-galactosides and contain comparable sequences of amino acids in their genes and proteins [1]. At that time, there were just four identified members, but now 15 members have been described in mammals, with similar proteins found in various animal species, as well as in ...
Fu-Tong, Liu, Ri-Yao, Yang, Jun, Saegusa, Huan-Yuan, Chen, Daniel K, Hsu   +4 more
openaire   +2 more sources

Examination of the Role of Galectins and Galectin Inhibitors in Endothelial Cell Biology

2014
The growth of new blood vessels is a key event in many (patho)physiological processes, including embryogenesis, wound healing, inflammatory diseases, and cancer. Neovascularization requires different, well-coordinated actions of endothelial cells, i.e., the cells lining the luminal side of all blood vessels.
Schulkens, I.A.E., Kleibeuker, E.A., Castricum, K.C.M., Griffioen, A.W., Thijssen, V.L.J.L.   +4 more
openaire   +4 more sources