The Role of Galectin-1 in Cancer Progression, and Synthetic Multivalent Systems for the Study of Galectin-1 [PDF]
International Journal of Molecular Sciences, 2016 This review discusses the role of galectin-1 in the tumor microenvironment. First, the structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin family of lectins, is a functionally dimeric galactoside-binding protein.
Mary Cloninger
exaly +3 more sources
Development and Use of a Galectin-1-Specific Nanobody for Tumor Imaging and Elucidating the Role of Galectin‑1 in Cancer. [PDF]
ACS Pharmacol Transl SciGalectin-1 (GAL-1) plays a crucial role in cancer biology, especially in triple-negative breast cancer (TNBC), where it facilitates immune evasion and tumor progression. This study presents G1N1, a novel nanobody that specifically targets GAL-1 and exhibits remarkable affinity and selectivity.
Granger Joly de Boissel P +12 more
europepmc +3 more sources
Galectin-1 in Obesity and Type 2 Diabetes
Metabolites, 2022 Galectin-1 is a carbohydrate-binding protein expressed in many tissues. In recent years, increasing evidence has emerged for the role of galectin-1 in obesity, insulin resistance and type 2 diabetes. Galectin-1 has been highly conserved through evolution
Emanuel Fryk +2 more
doaj +3 more sources
Galectin-1 as a predictive biomarker in ovarian cancer [PDF]
Journal of Ovarian Research, 2021 Aim There is an urgent need to set up a useful biomarker for ovarian cancer. Galectin-1 is a promising carbohydrate-binding protein which plays a remarkable role in various malignancies yet its clinical significance is questionable.
Mahak Masoodi +8 more
doaj +3 more sources
From adipokine to integrator: longitudinal galectin-1 changes mirror glycemic, hepatic, renal, and lipid remodeling after bariatric surgery [PDF]
Nutrition & DiabetesBackground Circulating galectin-1 levels increase with adiposity, and experimental data implicate this adipokine in the development of metabolic dysfunction.
Te-Hung Chen +6 more
doaj +2 more sources
The relationship between galectin-1 expression and the efficacy of anti-PD-1 therapy for non-small cell lung cancer patients [PDF]
Scientific ReportsWe herein examined the potential of galectin-1 expression to predict the efficacy of anti-PD-1 therapy for patients with non-small cell lung cancer (NSCLC).
Mari Tone +7 more
doaj +2 more sources
Galectin-1 Inhibition as a Strategy for Malignant Peripheral Nerve Sheath Tumor Treatment [PDF]
CellsNeurofibromatosis type 1 (NF1) is an inherited disorder that predisposes individuals to malignant peripheral nerve sheath tumors (MPNSTs), a highly aggressive sarcoma with limited treatment options and poor prognosis. This study explores the potential of
Hsiao-Chi Wang +6 more
doaj +2 more sources
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
Frontiers in Oncology, 2022 The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi +10 more
doaj +1 more source
Evaluation of galectins 1 and 3 expression in canine melanoma [PDF]
Pesquisa Veterinária Brasileira, 2021 : Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins.
Jéssica S. Garcia +6 more
doaj +1 more source
Galectin-1 for Neuroprotection? [PDF]
Immunity, 2012 Classically activated microglia (M1) are believed to play a key role in neuronal degeneration in multiple sclerosis (MS). In this issue of Immunity, Starossom et al. (2012) show that Galectin-1 exerts a neuroprotective function through glycosylation-dependent inactivation with M1 cells.
Nonaka, Motohiro, Fukuda, Minoru
openaire +2 more sources