Galectin-1 as a predictive biomarker in ovarian cancer [PDF]
Journal of Ovarian Research, 2021 Aim There is an urgent need to set up a useful biomarker for ovarian cancer. Galectin-1 is a promising carbohydrate-binding protein which plays a remarkable role in various malignancies yet its clinical significance is questionable.
Mahak Masoodi +8 more
doaj +4 more sources
The Role of Galectin-1 in Cancer Progression, and Synthetic Multivalent Systems for the Study of Galectin-1 [PDF]
International Journal of Molecular Sciences, 2016 This review discusses the role of galectin-1 in the tumor microenvironment. First, the structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin family of lectins, is a functionally dimeric galactoside-binding protein.
Mary J Cloninger
exaly +3 more sources
Development and Use of a Galectin-1-Specific Nanobody for Tumor Imaging and Elucidating the Role of Galectin‑1 in Cancer. [PDF]
ACS Pharmacol Transl SciGalectin-1 (GAL-1) plays a crucial role in cancer biology, especially in triple-negative breast cancer (TNBC), where it facilitates immune evasion and tumor progression. This study presents G1N1, a novel nanobody that specifically targets GAL-1 and exhibits remarkable affinity and selectivity.
Granger Joly de Boissel P +12 more
europepmc +3 more sources
Expression and significance of PIBF combined with Galectin-1 in cervical precancerous lesions [PDF]
Frontiers in MedicineObjectiveThis study aimed to discuss the significance of PIBF and Galectin-1 in cervical dysplasia tissue.MethodsThe expression of PIBF and Galectin-1 in precancerous tissues of cervical cancer was determined by the immunohistochemical method and ELISA ...
Hong Wang
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The relationship between galectin-1 expression and the efficacy of anti-PD-1 therapy for non-small cell lung cancer patients [PDF]
Scientific ReportsWe herein examined the potential of galectin-1 expression to predict the efficacy of anti-PD-1 therapy for patients with non-small cell lung cancer (NSCLC).
Mari Tone +7 more
doaj +2 more sources
Galectin-1 Inhibition as a Strategy for Malignant Peripheral Nerve Sheath Tumor Treatment [PDF]
CellsNeurofibromatosis type 1 (NF1) is an inherited disorder that predisposes individuals to malignant peripheral nerve sheath tumors (MPNSTs), a highly aggressive sarcoma with limited treatment options and poor prognosis. This study explores the potential of
Hsiao-Chi Wang +6 more
doaj +2 more sources
Cardiorespiratory fitness and the association with galectin-1 in middle-aged individuals. [PDF]
PLoS ONEGalectin-1 plays a functional role in human metabolism and the levels are altered in obesity and type 2 diabetes (T2D). This study investigates the association of cardiorespiratory fitness (CRF) with galectin-1 and the interconnection with body fatness ...
Daniel Arvidsson +6 more
doaj +2 more sources
Prognostic Influence of Galectin-1 in Gastric Adenocarcinoma. [PDF]
BiomedicinesGalectin-1 (Gal-1), a member of the human lectin family, has garnered attention for its association with aggressive behavior in human tumors, prompting research into the development of targeted drugs. This study aims to assess the staining pattern and prognostic significance of Gal-1 immunohistochemical expression in a homogeneous cohort of Western ...
Díaz Del Arco C +5 more
europepmc +6 more sources
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
Frontiers in Oncology, 2022 The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi +10 more
doaj +1 more source
Evaluation of galectins 1 and 3 expression in canine melanoma [PDF]
Pesquisa Veterinária Brasileira, 2021 : Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins.
Jéssica S. Garcia +6 more
doaj +1 more source