Results 1 to 10 of about 37,406 (116)

Diagnostic value of tear Galectin-1 and Galectin-3 in keratoconus: a prospective case-control study [PDF]

BMC Ophthalmology
Background This study aims to evaluate tear Galectin-1 and Galectin-3 levels in patients with keratoconus and healthy controls, assess their diagnostic performance, and investigate their associations with corneal tomography parameters.
Ali Kosekahya, Pinar Kosekahya, Huseyin Bugra Turk, Gamze Avcioglu, Özcan Erel, Aysen Erdem   +5 more
doaj   +2 more sources

From adipokine to integrator: longitudinal galectin-1 changes mirror glycemic, hepatic, renal, and lipid remodeling after bariatric surgery [PDF]

Nutrition & Diabetes
Background Circulating galectin-1 levels increase with adiposity, and experimental data implicate this adipokine in the development of metabolic dysfunction.
Te-Hung Chen, Young-Jen Lin, Wei-Shiung Yang, Po-Chu Lee, Chiung-Nien Chen, Ming-Tsan Lin, Po-Jen Yang   +6 more
doaj   +2 more sources

The relationship between galectin-1 expression and the efficacy of anti-PD-1 therapy for non-small cell lung cancer patients [PDF]

Scientific Reports
We herein examined the potential of galectin-1 expression to predict the efficacy of anti-PD-1 therapy for patients with non-small cell lung cancer (NSCLC).
Mari Tone, Yukihiro Yano, Junji Uchida, Masahide Mori, Hisashi Wada, Yoshito Takeda, Atsushi Kumanogoh, Kota Iwahori   +7 more
doaj   +2 more sources

Galectin-1 Inhibition as a Strategy for Malignant Peripheral Nerve Sheath Tumor Treatment [PDF]

Cells
Neurofibromatosis type 1 (NF1) is an inherited disorder that predisposes individuals to malignant peripheral nerve sheath tumors (MPNSTs), a highly aggressive sarcoma with limited treatment options and poor prognosis. This study explores the potential of
Hsiao-Chi Wang, Keila E. Torres, Roger Xia, Marcio H. Malogolowkin, Ssu-Wei Hsu, Ching-Hsien Chen, Tsung-Chieh Shih   +6 more
doaj   +2 more sources

Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?

Frontiers in Oncology, 2022
The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi, Yuanwei Shi, Danting Tang, Danting Tang, Xiaoqi Li, Xiaoqi Li, Xiaoli Xie, Yufu Ye, Yufu Ye, Lijuan Wang, Lijuan Wang   +10 more
doaj   +1 more source

Evaluation of galectins 1 and 3 expression in canine melanoma [PDF]

Pesquisa Veterinária Brasileira, 2021
: Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins.
Jéssica S. Garcia, Nicolle G.T.Q. Hazarbassanov, Júlia C. Nakamura, Victor Nowosh, Bruno Cogliati, Lilian Rose Marques de Sá, Cristina O. Massoco   +6 more
doaj   +1 more source

Prognostic Significance of Galectin-1 but Not Galectin-3 in Patients With Lung Adenocarcinoma After Radiation Therapy

Frontiers in Oncology, 2022
IntroductionTo investigate the role of tumor galectin-1 and galectin-3 in patients with lung adenocarcinoma after definitive radiation therapy.MethodsA total of 41 patients with localized lung adenocarcinoma undergoing thoracic radiation therapy without ...
Chun-Chieh Huang, Chun-Chieh Huang, I-Chieh Chuang, Yu-Li Su, Hao-Lun Luo, Ya-Chun Chang, Ya-Chun Chang, Jo-Ying Chen, Chang-Chun Hsiao, Chang-Chun Hsiao, Eng-Yen Huang, Eng-Yen Huang   +11 more
doaj   +1 more source

Galectin-1 in Obesity and Type 2 Diabetes

Metabolites, 2022
Galectin-1 is a carbohydrate-binding protein expressed in many tissues. In recent years, increasing evidence has emerged for the role of galectin-1 in obesity, insulin resistance and type 2 diabetes. Galectin-1 has been highly conserved through evolution
Emanuel Fryk, Vagner R. R. Silva, Per-Anders Jansson   +2 more
doaj   +1 more source

Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1

iScience, 2023
Summary: Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells.
Asha M. Rudjord-Levann, Zilu Ye, Lise Hafkenscheid, Sabrina Horn, Renske Wiegertjes, Mathias A.I. Nielsen, Ming Song, Caroline B.K. Mathiesen, Jesse Stoop, Sean Stowell, Per Thor Straten, Hakon Leffler, Sergey Y. Vakhrushev, Sally Dabelsteen, Jesper V. Olsen, Hans H. Wandall   +15 more
doaj   +1 more source

Galectin-1 accelerates high-fat diet-induced obesity by activation of peroxisome proliferator-activated receptor gamma (PPARγ) in mice

Cell Death and Disease, 2021
Galectin-1 contains a carbohydrate-recognition domain (CRD) as a member of the lectin family. Here, we investigated whether galectin-1 regulates adipogenesis and lipid accumulation.
Jung-Hwan Baek, Da-Hyun Kim, Jaegyeong Lee, Seok-Jun Kim, Kyung-Hee Chun   +4 more
doaj   +1 more source