Results 21 to 30 of about 29,735,201 (297)
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]
, 2012 The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y +59 more
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Frontiers in Neuroanatomy, 2021 Galectins are β-galactoside-binding lectins consisting of 15 members in mammals. Galectin-1,-3,-4,-8, and -9 are predominantly expressed in the central nervous system (CNS) and regulate various physiological and pathological events.
Junko Nio-Kobayashi, Tetsuya Itabashi
doaj +1 more source
Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]
, 2002 The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Holíkova, Zuzana +7 more
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Galectin-1 immunofluorescent staining.
, 2023 Nuclei are labeled by Hoescht stain (blue, left panels). Gall bladder neuroendocrine neoplasm demonstrates positive galectin-1 (red, middle and right top panels) immunofluorescence compared to negative control (normal canine kidney).
Daniel Paulsen (5500241) +9 more
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PLoS ONE, 2011 BackgroundGalectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the
Seok-Jun Kim +6 more
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Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair [PDF]
, 2011 Members of the galectin family of endogenous lectins are potent adhesion/growth-regulatory effectors. Their multi-functionality opens possibilities for their use in bioapplications. We studied whether human galectins induce the conversion of human dermal
Lacina, Lukas +21 more
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Biomolecules, 2023 Psoriasis is a complex disease that nowadays is considered not only a dermatosis but a kind of systemic disorder associated with many accompanying diseases. Metabolic complications leading to cardiovascular incidences are the cause of increased mortality
Julia Nowowiejska +5 more
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Monovalent Interactions of Galectin-1
Biochemistry, 2010 Galectin-1, a β-galactoside binding lectin involved in immunoregulation and cancer, binds natural and many synthetic multivalent glycoconjugates with an apparent glycoside cluster effect, that is, affinity above and beyond what would be expected from the concentration of the determinant sugar. Here we have analyzed the mechanism of such cluster effects
Emma, Salomonsson +11 more
openaire +2 more sources
Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions [PDF]
Nature Communications, 2015 Galectins are glycan-binding proteins involved in various biological processes including cell/cell interactions. During B-cell development, bone marrow stromal cells secreting galectin-1 (GAL1) constitute a specific niche for pre-BII cells. Besides binding glycans, GAL1 is also a pre-B cell receptor (pre-BCR) ligand that induces receptor clustering ...
Bonzi, Jeremy +9 more
openaire +3 more sources
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. [PDF]
, 2015 Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is ...
Martina Svensson +81 more
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