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Developing Galectin-3-Targeted Therapeutics in Diseases: Three Distinct Galectin-3 Segments for Targeting [PDF]
Expert Reviews in Molecular MedicineThe β-galactoside-binding protein galectin-3 is currently a hotly pursued therapeutic target in cancer, inflammation and fibrosis-associated diseases due to its multi-mode actions and broad impact on the pathogenesis and progress of the diseases. Various
Paulina Sindrewicz-Goral +3 more
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Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor
Journal for ImmunoTherapy of Cancer, 2021 Background PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppression that contribute to immunotherapy resistance. We hypothesized that Gal-3 blockade with belapectin (GR-MD-02) plus anti-PD-
William L Redmond +12 more
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Molecular Therapy: Nucleic Acids, 2023 Non-DNA-binding Stabilin-2/HARE receptors expressed on liver sinusoidal endothelial cells specifically bind to and internalize several classes of phosphorothioate antisense oligonucleotides (PS-ASOs).
Ekta Pandey, Edward N. Harris
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Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues
Biomolecules, 2021 Galectins comprise a family of soluble β-galactoside-binding proteins, which regulate a variety of key biological processes including cell growth, differentiation, survival, and death.
Jennifer D. Kaminker +1 more
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Journal of Extracellular Vesicles, 2022 Breast cancer cells release a large quantity of biocargo‐bearing extracellular vesicles (EVs), which mediate intercellular communication within the tumour microenvironment and promote metastasis.
Daniel Xin Zhang +16 more
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Molecules, 2021 Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective ...
Ludger Johannes
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Galectinology of Equine Pregnancy
Animals, 2022 Galectins are a family of proteins that bind to glycans, acting in a cytokine-like manner throughout the body. In the majority of mammalians, galectins have been found to be involved in pregnancy maintenance, but few studies have evaluated this in the ...
Carleigh E. Fedorka +2 more
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Galectins can serve as biomarkers in COVID-19: A comprehensive systematic review and meta-analysis
Frontiers in Immunology, 2023 BackgroundGalectins are an eleven-member class of lectins in humans that function as immune response mediators and aberrancies in their expression are commonly associated with immunological diseases.
Amir Hossein Behnoush +7 more
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“Repair Me if You Can”: Membrane Damage, Response, and Control from the Viral Perspective
Cells, 2020 Cells are constantly challenged by pathogens (bacteria, virus, and fungi), and protein aggregates or chemicals, which can provoke membrane damage at the plasma membrane or within the endo-lysosomal compartments.
Coralie F. Daussy, Harald Wodrich
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FEBS Open Bio, 2022 We previously observed that genomic loss of galectin‐3 (Gal‐3; encoded by Lgals3) in mice has a significant protective effect on age‐related bone loss.
Kevin A. Maupin +5 more
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