Results 41 to 50 of about 51,657 (292)
NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
Galectin-2, Galectins-5 and -9, and Galectins-4 and -6.
Trends in Glycoscience and Glycotechnology, 1997 現在、哺乳類には10種類のガレクチンがあることが示されている。この章ではそのうち5つについて、各ガレクチンの発見の経緯と特徴について述べようと思う。ガレクチン-2はガレクチン-1と同様、14kDaのサブユニットが2量体構造をした分子で、腸上皮細胞に発現している。ガレクチン-5は15kDaの単量体ガレクチンで、赤血球に発現している。最近発見されたガレクチン-9は多くの組織で発現している36kDaのタンパク質で、2つの糖認識ドメイン (CRD) からなり、このうちC-末端側のCRDがガレクチン-5と非常に高い類似性を示す。ガレクチン-4と-6は互いにきわめて似た分子で、それぞれ36kDaと34kDaの分子量を持ち、やはりともに2つのCRDからなり、両者とも消化管の上皮細胞で発現している。
Gitt, Michael A. +2 more
openaire +2 more sources
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
A Synthetic Galectin Mimic [PDF]
Angewandte Chemie, 2021 AbstractGalectins are a galactoside specific subclass of carbohydrate binding proteins (lectins) involved in various cellular activities, certain cancers, infections, inflammations, and many other biological processes. The molecular basis for the selectivity of galectins is well‐documented and revolves around appropriate interaction complementarity: an
Brian J. J. Timmer +3 more
openaire +6 more sources
The Role of Anti-Viral Effector Molecules in Mollusc Hemolymph
Biomolecules, 2022 Molluscs are major contributors to the international and Australian aquaculture industries, however, their immune systems remain poorly understood due to limited access to draft genomes and evidence of divergences from model organisms.
Angus Watson +4 more
doaj +1 more source
Galectin-8 and galectin-9 are novel substrates for thrombin [PDF]
Glycobiology, 2006 Galectin-8 and galectin-9, which each consist of two carbohydrate recognition domains (CRDs) joined by a linker peptide, belong to the tandem-repeat-type subclass of the galectin family. Alternative splicing leads to the formation of at least two and three distinct splice variants (isoforms) of galectin-8 and galectin-9, respectively, with tandem ...
Nozomu, Nishi +4 more
openaire +2 more sources
Teladorsagia Circumcincta Galectin-Mucosal Interactome in Sheep
Veterinary Sciences, 2021 Teladorsagia circumcincta is the most important gastrointestinal parasite in the livestock industry in temperate regions around the world, causing great economic losses.
Nur Nasuha Hafidi +7 more
doaj +1 more source
Galectin-1 and galectin-3 as modulators of systemic CD4+ T-lymphocyte balance in colorectal cancer
Бюллетень сибирской медициныAim. To evaluate the relationships between plasma levels of galectin-1 and galectin-3 and the composition of CD4+ T-lymphocyte subpopulations (Th1, Th17, and Treg) in patients with colorectal cancer (CRC) and to determine a direct in vitro modulatory ...
V. S. Poletika +4 more
doaj +1 more source
Frontiers in Oncology, 2016 Aberrant glycosylation of cell membrane proteins is a universal feature of cancer cells. One of the most common glycosylation changes in epithelial cancer is the increased occurrence of the oncofetal Thomsen-Friedenreich disaccharide Galβ1-3GalNAc (T or ...
Paulina eSindrewicz +2 more
doaj +1 more source
Effect of galectin-3 in the pathogenesis of arteriovenous fistula stenosis formation
Renal Failure, 2021 Objective This study sought to investigate the effect of local expression of galectin-3 in the development of stenotic arteriovenous fistula (AVF). Methods We collected stenotic venous tissues, adjacent nonstenotic venous tissues, and blood samples from ...
Lin Ruan +6 more
doaj +1 more source