Results 11 to 20 of about 53,384 (285)
Current Biology, 2022 Banfer and Jacob introduce us to galectins - β-galactoside-binding lectins - and their range of functions in multicellular organisms.
Sebastian, Bänfer, Ralf, Jacob
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis [PDF]
, 2009 Fibroblasts are important regulators of inflammatory processes. The phenotype of fibroblasts differ according to anatomical site which may dtermine immune functions such as leukocyte accumulation and predilection for inflammatory disease in certain ...
Bik, Magadelena Anna
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Journal of Cell Science, 2018 ABSTRACT Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis, cancer and heart disease.
Johannes, Ludger +2 more
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Brain Pathology, 2009 AbstractMalignant gliomas, especially glioblastomas, are associated with a dismal prognosis. Despite advances in diagnosis and treatment, glioblastoma patients still have a median survival expectancy of only 14 months. This poor prognosis can be at least partly explained by the fact that glioma cells diffusely infiltrate the brain parenchyma and ...
Le Mercier, Marie +4 more
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Galectins in the Tumor Microenvironment: Focus on Galectin-1 [PDF]
, 2020 In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies.
Neus, Martínez-Bosch, Pilar, Navarro
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FEBS Open Bio, 2022 We previously observed that genomic loss of galectin‐3 (Gal‐3; encoded by Lgals3) in mice has a significant protective effect on age‐related bone loss.
Kevin A. Maupin +5 more
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Atg8ylation as a general membrane stress and remodeling response
Cell Stress, 2021 The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
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Galectin-1 and Galectin-3 in Chronic Pancreatitis [PDF]
Laboratory Investigation, 2000 Galectin-1 and galectin-3 have important functions in cell-cell interactions, cell adhesion to extracellular matrix, the organization of extracellular matrix, and tissue remodeling. To assess their potential role in chronic pancreatitis (CP), we examined their expression by Northern blot analysis, in situ hybridization, immunohistochemistry, and ...
Wang L +7 more
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Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function
Frontiers in Immunology, 2020 The tumor microenvironment (TME) is composed of multiple infiltrating host cells (e.g., endothelial cells, fibroblasts, lymphocytes, and myeloid cells), extracellular matrix, and various secreted or cell membrane-presented molecules.
Gustavo Rodrigues Rossi +2 more
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Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]
, 2012 The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y +59 more
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