Results 31 to 40 of about 113,439,941 (280)

Monovalent Interactions of Galectin-1

Biochemistry, 2010
Galectin-1, a β-galactoside binding lectin involved in immunoregulation and cancer, binds natural and many synthetic multivalent glycoconjugates with an apparent glycoside cluster effect, that is, affinity above and beyond what would be expected from the concentration of the determinant sugar. Here we have analyzed the mechanism of such cluster effects
Emma, Salomonsson, Amaia, Larumbe, Johan, Tejler, Erik, Tullberg, Hanna, Rydberg, Anders, Sundin, Areej, Khabut, Torbjörn, Frejd, Yuri D, Lobsanov, James M, Rini, Ulf J, Nilsson, Hakon, Leffler   +11 more
openaire   +2 more sources

Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions [PDF]

Nature Communications, 2015
Galectins are glycan-binding proteins involved in various biological processes including cell/cell interactions. During B-cell development, bone marrow stromal cells secreting galectin-1 (GAL1) constitute a specific niche for pre-BII cells. Besides binding glycans, GAL1 is also a pre-B cell receptor (pre-BCR) ligand that induces receptor clustering ...
Bonzi, Jeremy, Bornet, Olivier, Betzi, Stéphane, Kasper, Brian, Mahal, Lara, Mancini, Stéphane, Schiff, Claudine, Sebban-Kreuzer, Corinne, Guerlesquin, Francoise, Elantak, Latifa   +9 more
openaire   +3 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Glycodendrimers: tools to explore multivalent galectin-1 interactions

Beilstein Journal of Organic Chemistry, 2015
Four generations of lactose-functionalized polyamidoamine (PAMAM) were employed to further the understanding of multivalent galectin-1 mediated interactions.
Jonathan M. Cousin, Mary J. Cloninger
doaj   +1 more source

The expression profiles of the galectin gene family in primary and metastatic papillary thyroid carcinoma with particular emphasis on galectin-1 and galectin-3 expression [PDF]

, 2014
Introduction Galectin family members have been demonstrated to be abnormally expressed in cancer at the protein and mRNA level. This study investigated the levels of galectin proteins and mRNA expression in a large cohort of patients with papillary ...
Sullivan, Emily, Gopalan, Vinod, Rahman, Md Atiqur, Dolan-Evans, Elliot, Smith, Robert A., Salajegheh, Ali, Lam, Alfred King-Yin, Irani, Soussan, Vosgha, Haleh, Smith, Robert Anthony   +9 more
core   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Galectin-1 and -9 in angiogenesis: A sweet couple [PDF]

Glycobiology, 2014
The growth of new blood vessels out of the pre-existing vasculature, i.e., angiogenesis, is executed by endothelial cells that normally form the inner lining of blood vessels. During angiogenesis, these cells exert different activities which require interactions with other cells and with the extracellular environment.
Thijssen, V.L.J.L., Griffioen, A.W.
openaire   +2 more sources

Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Immune tolerance is considered the only way to manage liver transplantation (LT). The current study hypothesized that galectin-1 via the activation of hepatic stellate cells (HSCs) is capable of inducing immune tolerance in LT.
Zhi-Jun Jiang, Qing-Hua Shen, Hai-Yong Chen, Zhe Yang, Ming-Qi Shuai, Shusen Zheng   +5 more
doaj   +1 more source

Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis

BMC Cancer, 2023
Background Peritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors in GC and may be key in GC peritoneal metastasis. Methods In this study, we elucidated
Xianhe Shen, Huilan Liu, Haihua Zhou, Zhiyi Cheng, Guiyuan Liu, Chuanjiang Huang, Rongrong Dou, Fuxing Liu, Xiaolan You   +8 more
doaj   +1 more source

The role of galectin-1 in type 2 diabetes. Clinical and experimental studies [PDF]

, 2022
Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes.
Fryk, Emanuel
core   +1 more source