Results 51 to 60 of about 21,276,578 (296)
Galectin-1 as an oncotarget in gliomas and melanomas
Oncotarget, 2011 Galectin-1 is a 14.5-kDa β-galactoside-binding protein that belongs to a 15-member protein family expressed by many different cell types. It exerts major roles in the immune system [1,2] and is involved in the progression of various cancer types [3], including melanomas and gliomas [4].
Lefranc, Florence +2 more
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Biomolecules & Biomedicine, 2020 Ulcerative colitis is an inflammatory bowel disease that affects a large number of people around the world. Galectin-1 is a β-galactoside-binding lectin with a broad range of biological activities.
Pelin Arda-Pirincci, Guliz Aykol-Celik
doaj +1 more source
Galectin-1 as a potential cancer target [PDF]
British Journal of Cancer, 2005 Galectins are a family of structurally related carbohydrate-binding proteins, which are defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition domain. Galectin-1, a member of this family, contributes to different events associated with cancer biology, including tumour ...
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Galectin-1 is a poor prognostic factor in patients with glioblastoma multiforme after radiotherapy
BMC Cancer, 2018 Background Galectin-1, a radioresistance marker, was found in our previous study to be a prognostic factor for cervical cancer. The aim of current study is to determine the prognostic significance of the galectin-1 expression level in patients with ...
Shang-Yu Chou +3 more
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Galectin-1: a small protein with major functions [PDF]
Glycobiology, 2006 Galectins are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of biological activity. The intracellular and extracellular activity of Gal-1 has been described.
Camby, Isabelle +3 more
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The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer [PDF]
, 2003 Galectin-3 is an apoptosis-related gene previously found to be over-expressed in invasive tumours and to cause in v itroinvasiveness and metastasis in colon, breast and thyroid follicular cancer cells.
Linehan, Rasha
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Galectin-1 Regulates RNA Expression and Alternative Splicing of Angiogenic Genes in HUVECs
Frontiers in Bioscience-Landmark, 2023 Background: Angiogenesis is essential for tissue development, and therefore its dysregulation can cause various diseases, including cerebrovascular disease. Galectin-1, encoded by the lectin galactoside-binding soluble-1 gene (LGALS1), has critical roles
Jiajun Wei +3 more
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Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Advanced Science, EarlyView.Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu +12 more
wiley +1 more source