Results 51 to 60 of about 29,735,201 (297)
Enhanced Susceptibility of Galectin-1 Deficient Mice to Experimental Colitis
Frontiers in Immunology, 2021 Galectin-1 is a β-galactoside-binding lectin, ubiquitously expressed in stromal, epithelial, and different subsets of immune cells. Galectin-1 is the prototype member of the galectin family which shares specificity with β-galactoside containing proteins ...
Raquel Fernandez-Perez +13 more
doaj +1 more source
Galectin-1 as an oncotarget in gliomas and melanomas
Oncotarget, 2011 Galectin-1 is a 14.5-kDa β-galactoside-binding protein that belongs to a 15-member protein family expressed by many different cell types. It exerts major roles in the immune system [1,2] and is involved in the progression of various cancer types [3], including melanomas and gliomas [4].
Lefranc, Florence +2 more
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The role of galectin-1 in type 2 diabetes. Clinical and experimental studies [PDF]
, 2022 Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes.
Fryk, Emanuel
core +1 more source
Galectin-1 is a poor prognostic factor in patients with glioblastoma multiforme after radiotherapy
BMC Cancer, 2018 Background Galectin-1, a radioresistance marker, was found in our previous study to be a prognostic factor for cervical cancer. The aim of current study is to determine the prognostic significance of the galectin-1 expression level in patients with ...
Shang-Yu Chou +3 more
doaj +1 more source
Galectin-1: a small protein with major functions [PDF]
Glycobiology, 2006 Galectins are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of biological activity. The intracellular and extracellular activity of Gal-1 has been described.
Camby, Isabelle +3 more
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Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Biomolecules & Biomedicine, 2020 Ulcerative colitis is an inflammatory bowel disease that affects a large number of people around the world. Galectin-1 is a β-galactoside-binding lectin with a broad range of biological activities.
Pelin Arda-Pirincci, Guliz Aykol-Celik
doaj +1 more source
Animal lectins as cell adhesion molecules [PDF]
, 1998 Protein-carbohydrate interaction is exploited in cell adhesion mechanisms besides the recognition of peptide motifs. The sugar code thus significantly contributes to the intriguing specificity of cellular selection of binding partners.
Kaltner, H., Stierstorfer, B.
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Advanced Functional Materials, EarlyView.Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro +25 more
wiley +1 more source
Galectins in the Tumor Microenvironment: Focus on Galectin-1 [PDF]
, 2020 In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies.
Neus, Martínez-Bosch, Pilar, Navarro
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