Results 71 to 80 of about 29,735,201 (297)

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Association of C-type lectin-like receptor 2 and galectin-1 with portal vein system thrombosis in HBV-related liver cirrhosis

Frontiers in Medicine, 2023
Background and aimsHepatitis B virus (HBV) infection is the most common cause of liver cirrhosis. Portal venous system thrombosis (PVST) is a major complication of liver cirrhosis.
Yiyan Zhang, Yiyan Zhang, Xintong Zhang, Xiangbo Xu, Xiangbo Xu, Xiaozhong Guo, Shixue Xu, Shixue Xu, Shaoze Ma, Shaoze Ma, Jihong Chen, Jihong Chen, Xingshun Qi   +12 more
doaj   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Galectins 1, 3 and 9 in patients with systemic lupus erythematosus: is there an association with disease activity or clinical manifestations?

Современная ревматология
Objective. To compare serum concentrations of galectins 1, 3 and 9 in women with systemic lupus erythematosus (SLE) and healthy donors; to assess the relationship of these biomarkers with disease activity and specific clinical manifestations.Material and
L. V. Kondrateva, T. A. Panafidina, Yu. N. Gorbunova, T. V. Popkova, M. E. Diatroptov, A. S. Avdeeva   +5 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Galectin-1 Ameliorates Influenza A H1N1pdm09 Virus-Induced Acute Lung Injury

Frontiers in Microbiology, 2020
Influenza remains one of the major epidemic diseases worldwide. Acute lung injury mainly caused by excessive pro-inflammatory host immune responses leads to high mortality rates in severe influenza patients.
Jiaqi Bao, Jiaqi Bao, Jiaqi Bao, Xiaochen Wang, Xiaochen Wang, Xiaochen Wang, Sijia Liu, Sijia Liu, Sijia Liu, Qianda Zou, Qianda Zou, Qianda Zou, Shufa Zheng, Shufa Zheng, Shufa Zheng, Shufa Zheng, Fei Yu, Fei Yu, Fei Yu, Yu Chen, Yu Chen, Yu Chen, Yu Chen   +22 more
doaj   +1 more source

Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice [PDF]

, 2013
PMCID: PMC3579848This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Karla J. Castellanos (7918193), Perretti, M, Akasheh, RT, Mauro Perretti (241694), Rand T Akasheh, Jingbo Pang, Jingbo Pang (381396), Pini, M, Castellanos Karla J., Dianne Cooper, Davina H Rhodes, Mauro Perretti, Rhodes Davina H., Giamila Fantuzzi (315958), Fantuzzi, G, Fantuzzi Giamila, Cabay Robert J., Davina H. Rhodes (315954), Rand T. Akasheh (7918190), Cooper Dianne, Cabay, RJ, Pang Jingbo, Robert J. Cabay (7918196), Maria Pini (315953), Robert J Cabay, Pini Maria, Castellanos, KJ, Karla J Castellanos, Rhodes, DH, Maria Pini, Akasheh Rand T., Dianne Cooper (381398), Cooper, D, Giamila Fantuzzi, Pang, J, Perretti Mauro   +35 more
core   +1 more source

Galectin expression profiling identifies galectin-1 and Galectin-9Δ5 as prognostic factors in stage I/II non-small cell lung cancer.

PLoS ONE, 2014
Approximately 30-40% of the patients with early stage non-small cell lung cancer (NSCLC) will present with recurrent disease within two years of resection.
Iris A Schulkens, Roy Heusschen, Vivian van den Boogaart, Robert-Jan van Suylen, Anne-Marie C Dingemans, Arjan W Griffioen, Victor L Thijssen   +6 more
doaj   +1 more source