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Galectin-1 Pulls the Strings on VEGFR2 [PDF]
Cell, 2014 Anti-vascular endothelial growth factor (VEGF) cancer immunotherapy targets angiogenesis but development of resistance in patients is common. In this issue of Cell, Croci et al. identify a complex set of mechanisms by which galectin-1 prolongs cell-surface retention of VEGF receptor 2 (VEGFR2) and stimulates VEGF-independent tumor angiogenesis.
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Galectin-1 and galectin-3 as modulators of systemic CD4+ T-lymphocyte balance in colorectal cancer
Бюллетень сибирской медициныAim. To evaluate the relationships between plasma levels of galectin-1 and galectin-3 and the composition of CD4+ T-lymphocyte subpopulations (Th1, Th17, and Treg) in patients with colorectal cancer (CRC) and to determine a direct in vitro modulatory ...
V. S. Poletika +4 more
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Бюллетень сибирской медицины, 2020 The aim of the study was to characterize the features of the subpopulation composition and cytokine-secretory activity of T lymphocytes (Th1, Th17 and Treg) in relation to the concentration of galectin-1 and galectin-3 in the blood of patients with colon
V. S. Poletika +8 more
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Galectinology of Equine Pregnancy
Animals, 2022 Galectins are a family of proteins that bind to glycans, acting in a cytokine-like manner throughout the body. In the majority of mammalians, galectins have been found to be involved in pregnancy maintenance, but few studies have evaluated this in the ...
Carleigh E. Fedorka +2 more
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“Supra”molecular Recognition of Galectin 1
Chemistry & Biology, 2007 In this issue of Chemistry & Biology, Belitsky et al. [1] elegantly describe the use of supramolecular complexes of sugars to multivalently target Galectin-1 (Gal-1), a lectin involved in the organization of cell surface glycoproteins, signaling, cell death, and cancer metastasis.
Disney, Matthew D. +1 more
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The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer [PDF]
, 2003 Galectin-3 is an apoptosis-related gene previously found to be over-expressed in invasive tumours and to cause in v itroinvasiveness and metastasis in colon, breast and thyroid follicular cancer cells.
Linehan, Rasha
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Frontiers in Immunology, 2017 Many infectious diseases are characterized by the development of immunoregulatory pathways that contribute to pathogen persistence and associated disease symptoms.
Patrick T. Bunn +15 more
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Galectin-1 as an oncotarget in gliomas and melanomas
Oncotarget, 2011 Galectin-1 is a 14.5-kDa β-galactoside-binding protein that belongs to a 15-member protein family expressed by many different cell types. It exerts major roles in the immune system [1,2] and is involved in the progression of various cancer types [3], including melanomas and gliomas [4].
Lefranc, Florence +2 more
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Survival mechanisms in B lymphoid malignancies and associated therapies [PDF]
, 2011 PhDThe apoptotic pathway plays critical roles in regulating lymphocyte survival throughout B cell development, maturation and differentiation. The whole process involves clonal expansion. In the normal B lymphocyte population the majority of cells and
Su, Bo
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PLoS ONE, 2011 Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding ...
Michael C Carlsson +11 more
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