Results 41 to 50 of about 29,735,201 (297)
Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis
BMC Cancer, 2023 Background Peritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors in GC and may be key in GC peritoneal metastasis. Methods In this study, we elucidated
Xianhe Shen +8 more
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Galectin-1 Pulls the Strings on VEGFR2 [PDF]
Cell, 2014 Anti-vascular endothelial growth factor (VEGF) cancer immunotherapy targets angiogenesis but development of resistance in patients is common. In this issue of Cell, Croci et al. identify a complex set of mechanisms by which galectin-1 prolongs cell-surface retention of VEGF receptor 2 (VEGFR2) and stimulates VEGF-independent tumor angiogenesis.
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Бюллетень сибирской медицины, 2020 The aim of the study was to characterize the features of the subpopulation composition and cytokine-secretory activity of T lymphocytes (Th1, Th17 and Treg) in relation to the concentration of galectin-1 and galectin-3 in the blood of patients with colon
V. S. Poletika +8 more
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Galectinology of Equine Pregnancy
Animals, 2022 Galectins are a family of proteins that bind to glycans, acting in a cytokine-like manner throughout the body. In the majority of mammalians, galectins have been found to be involved in pregnancy maintenance, but few studies have evaluated this in the ...
Carleigh E. Fedorka +2 more
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Galectin-1 and galectin-3 as modulators of systemic CD4+ T-lymphocyte balance in colorectal cancer
Бюллетень сибирской медициныAim. To evaluate the relationships between plasma levels of galectin-1 and galectin-3 and the composition of CD4+ T-lymphocyte subpopulations (Th1, Th17, and Treg) in patients with colorectal cancer (CRC) and to determine a direct in vitro modulatory ...
V. S. Poletika +4 more
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“Supra”molecular Recognition of Galectin 1
Chemistry & Biology, 2007 In this issue of Chemistry & Biology, Belitsky et al. [1] elegantly describe the use of supramolecular complexes of sugars to multivalently target Galectin-1 (Gal-1), a lectin involved in the organization of cell surface glycoproteins, signaling, cell death, and cancer metastasis.
Disney, Matthew D. +1 more
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PLoS ONE, 2011 Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding ...
Michael C Carlsson +11 more
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Galectin-1 as a potential cancer target [PDF]
British Journal of Cancer, 2005 Galectins are a family of structurally related carbohydrate-binding proteins, which are defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition domain. Galectin-1, a member of this family, contributes to different events associated with cancer biology, including tumour ...
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Frontiers in Microbiology, 2022 Trypanosoma cruzi, the protozoan parasite causative agent of Chagas disease, affects about seven million people worldwide, representing a major global public health concern with relevant socioeconomic consequences, particularly in developing countries ...
Carolina V. Poncini +5 more
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Frontiers in Immunology, 2017 Many infectious diseases are characterized by the development of immunoregulatory pathways that contribute to pathogen persistence and associated disease symptoms.
Patrick T. Bunn +15 more
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