Results 11 to 20 of about 21,276,578 (296)

Oxidized galectin-1 reduces lipopolysaccharide-induced increase of proinflammatory cytokine mRNA in cultured macrophages

Clinical, Cosmetic and Investigational Dentistry, 2011
Yukie Kogawa1, Kou Nakajima1, Kenichi Sasaguri1, Nobushiro Hamada2, Haruhisa Kawasaki3, Sadao Sato1, Toshihiko Kadoya4, Hidenori Horie51Department of Orthodontics, 2Department of Oral Microbiology, Kanagawa Dental College, Yokosuka; 3Keio University ...
Yukie Kogawa, Kou Nakajima, Kenichi Sasaguri, et al   +3 more
doaj   +1 more source

Prognostic Significance of Galectin-1 but Not Galectin-3 in Patients With Lung Adenocarcinoma After Radiation Therapy

Frontiers in Oncology, 2022
IntroductionTo investigate the role of tumor galectin-1 and galectin-3 in patients with lung adenocarcinoma after definitive radiation therapy.MethodsA total of 41 patients with localized lung adenocarcinoma undergoing thoracic radiation therapy without ...
Chun-Chieh Huang, Chun-Chieh Huang, I-Chieh Chuang, Yu-Li Su, Hao-Lun Luo, Ya-Chun Chang, Ya-Chun Chang, Jo-Ying Chen, Chang-Chun Hsiao, Chang-Chun Hsiao, Eng-Yen Huang, Eng-Yen Huang   +11 more
doaj   +1 more source

Galectin-1 for Neuroprotection? [PDF]

Immunity, 2012
Classically activated microglia (M1) are believed to play a key role in neuronal degeneration in multiple sclerosis (MS). In this issue of Immunity, Starossom et al. (2012) show that Galectin-1 exerts a neuroprotective function through glycosylation-dependent inactivation with M1 cells.
Nonaka, Motohiro, Fukuda, Minoru
openaire   +2 more sources

Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1

iScience, 2023
Summary: Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells.
Asha M. Rudjord-Levann, Zilu Ye, Lise Hafkenscheid, Sabrina Horn, Renske Wiegertjes, Mathias A.I. Nielsen, Ming Song, Caroline B.K. Mathiesen, Jesse Stoop, Sean Stowell, Per Thor Straten, Hakon Leffler, Sergey Y. Vakhrushev, Sally Dabelsteen, Jesper V. Olsen, Hans H. Wandall   +15 more
doaj   +1 more source

Galectin-1 in Obesity and Type 2 Diabetes

Metabolites, 2022
Galectin-1 is a carbohydrate-binding protein expressed in many tissues. In recent years, increasing evidence has emerged for the role of galectin-1 in obesity, insulin resistance and type 2 diabetes. Galectin-1 has been highly conserved through evolution
Emanuel Fryk, Vagner R. R. Silva, Per-Anders Jansson   +2 more
doaj   +1 more source

Galectin-1 accelerates high-fat diet-induced obesity by activation of peroxisome proliferator-activated receptor gamma (PPARγ) in mice

Cell Death and Disease, 2021
Galectin-1 contains a carbohydrate-recognition domain (CRD) as a member of the lectin family. Here, we investigated whether galectin-1 regulates adipogenesis and lipid accumulation.
Jung-Hwan Baek, Da-Hyun Kim, Jaegyeong Lee, Seok-Jun Kim, Kyung-Hee Chun   +4 more
doaj   +1 more source

Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. [PDF]

PLoS ONE, 2015
Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ...
Simone Punt, Victor L Thijssen, Johannes Vrolijk, Cornelis D de Kroon, Arko Gorter, Ekaterina S Jordanova   +5 more
doaj   +1 more source

Chemokines modulate glycan binding and the immunoregulatory activity of galectins

Communications Biology, 2021
Sanjurjo et al investigate the role of galectins in immunomodulation, reporting that chemokines can control galectin immunomodulatory function through a mechanism involving galectin-chemokine binding pairs.
Lucía Sanjurjo, Iris A. Schulkens, Pauline Touarin, Roy Heusschen, Ed Aanhane, Kitty C. M. Castricum, Tanja D. De Gruijl, Ulf J. Nilsson, Hakon Leffler, Arjan W. Griffioen, Latifa Elantak, Rory R. Koenen, Victor L. J. L. Thijssen   +12 more
doaj   +1 more source

Galectin-1 and Galectin-3 expression in colon cancer and its correlation with tumor invasion, differentiation, and metastatic spread

Фундаментальная и клиническая медицина, 2021
Aim. To study the expression of galectin-1 and galectin-3 in colon cancer and the levels of these proteins in the peripheral blood in relation to the differentiation, invasion, and metastatic dissemination.Materials and Methods.
Yu. V. Kolobovnikova, O. I. Urazova, V. S. Poletika, G. V. Reyngardt, E. V. Romanova, A. V. Kurnosenko, A. I. Dmitrieva, K. I. Yankovich, M. Yu. Grishchenko   +8 more
doaj   +1 more source

Differential Cellular Expression of Galectin-1 and Galectin-3 After Intracerebral Hemorrhage

Frontiers in Cellular Neuroscience, 2019
Intracerebral hemorrhage (ICH) is a devastating sub-type of stroke with no proven treatment. Given the emerging role of Galectin-1 and Galectin-3 in neuroimmune responses, the objective of the current manuscript is to elucidate hemorrhagic-injury induced
Frederick Bonsack, Sangeetha Sukumari-Ramesh   +1 more
doaj   +1 more source