Results 11 to 20 of about 113,439,941 (280)
Galectin-1 as a predictive biomarker in ovarian cancer [PDF]
Journal of Ovarian Research, 2021 Aim There is an urgent need to set up a useful biomarker for ovarian cancer. Galectin-1 is a promising carbohydrate-binding protein which plays a remarkable role in various malignancies yet its clinical significance is questionable.
Mahak Masoodi +8 more
doaj +3 more sources
Clinical, Cosmetic and Investigational Dentistry, 2011 Yukie Kogawa1, Kou Nakajima1, Kenichi Sasaguri1, Nobushiro Hamada2, Haruhisa Kawasaki3, Sadao Sato1, Toshihiko Kadoya4, Hidenori Horie51Department of Orthodontics, 2Department of Oral Microbiology, Kanagawa Dental College, Yokosuka; 3Keio University ...
Yukie Kogawa +3 more
doaj +1 more source
The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis [PDF]
, 2009 Fibroblasts are important regulators of inflammatory processes. The phenotype of fibroblasts differ according to anatomical site which may dtermine immune functions such as leukocyte accumulation and predilection for inflammatory disease in certain ...
Bik, Magadelena Anna
core +7 more sources
Role of Galectin-1 in the Pathogenesis of Melanoma. [PDF]
J Cancer Sci Clin TherGalectins (Gal) are β-galactoside-binding endogenous lectins involved in a wide variety of angiogenic and immune functions throughout many tissues. Galectin 1 (Gal-1) is an important member of the galectin family, acting as a central regulator in immune cells, tumor immune evasion, metastasis, angiogenesis, and therapy resistance, especially in ...
Kim G +5 more
europepmc +3 more sources
Taloside Inhibitors of Galectin-1 and Galectin-3
Chemical Biology & Drug Design, 2012 Galectin-1 and galectin-3 have roles in cancer and inflammation. Galectin-1 has recently emerged as a significant protein produced by tumour cells to promote tumour development, angiogenesis and metastasis and consequently represents an important target ...
Collins, Patrick M. +18 more
core +4 more sources
Galectin-1 for Neuroprotection? [PDF]
Immunity, 2012 Classically activated microglia (M1) are believed to play a key role in neuronal degeneration in multiple sclerosis (MS). In this issue of Immunity, Starossom et al. (2012) show that Galectin-1 exerts a neuroprotective function through glycosylation-dependent inactivation with M1 cells.
Nonaka, Motohiro, Fukuda, Minoru
openaire +2 more sources
Development and Use of a Galectin-1-Specific Nanobody for Tumor Imaging and Elucidating the Role of Galectin‑1 in Cancer. [PDF]
ACS Pharmacol Transl SciGalectin-1 (GAL-1) plays a crucial role in cancer biology, especially in triple-negative breast cancer (TNBC), where it facilitates immune evasion and tumor progression. This study presents G1N1, a novel nanobody that specifically targets GAL-1 and exhibits remarkable affinity and selectivity.
Granger Joly de Boissel P +12 more
europepmc +3 more sources
Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. [PDF]
PLoS ONE, 2015 Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ...
Simone Punt +5 more
doaj +1 more source
Galectin-1 immunofluorescent staining.
, 2023 Nuclei are labeled by Hoescht stain (blue, left panels). Gall bladder neuroendocrine neoplasm demonstrates positive galectin-1 (red, middle and right top panels) immunofluorescence compared to negative control (normal canine kidney).
Daniel Paulsen (5500241) +9 more
core +1 more source
Chemokines modulate glycan binding and the immunoregulatory activity of galectins
Communications Biology, 2021 Sanjurjo et al investigate the role of galectins in immunomodulation, reporting that chemokines can control galectin immunomodulatory function through a mechanism involving galectin-chemokine binding pairs.
Lucía Sanjurjo +12 more
doaj +1 more source