Results 21 to 30 of about 121,769 (312)

Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion

Nature Communications, 2022
Metabolic conditions associated with alterations of the gut microbiome, such as obesity and diabetes, predispose to gallstone disease. Here the authors demonstrate that the gut microbiome, in particular the genus Desulfovibrionale, contribute to ...
Hai Hu, Wentao Shao, Qian Liu, Ning Liu, Qihan Wang, Jin Xu, Xin Zhang, Zhenkun Weng, Qifan Lu, Long Jiao, Chaobo Chen, Haidong Sun, Zhaoyan Jiang, Xiaoping Zhang, Aihua Gu   +14 more
doaj   +1 more source

Laparoscopic or open liver resection for intrahepatic cholangiocarcinoma: A meta-analysis and systematic review

Frontiers in Oncology, 2023
BackgroundAlthough laparoscopic hepatectomy has been widely used in the treatment of benign and malignant liver diseases, its applicability in intrahepatic cholangiocarcinoma (ICC) is controversial.
Xin Zhao, Xin Zhao, Feng-wei Gao, Feng-wei Gao, Feng-wei Gao, Kang-yi Jiang, Kang-yi Jiang, Jie Yang, Jie Yang, Qing-yun Xie, Qing-yun Xie, Jie Gong, Jie Gong, Man-yu Yang, Tian-yang Mao, Ze-hua Lei, Ze-hua Lei   +16 more
doaj   +1 more source

IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization

Translational Oncology, 2023
Introduction: N6-methyladenosine (m6A) is an emerging epigenetic modification, which plays a crucial role in the development of cancer. Nevertheless, the underlying mechanism of m6A-associated proteins and m6A modification in gallbladder cancer remains ...
Jian Qin, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding, Hai Hu, Jingli Cai   +7 more
doaj   +1 more source

Relation of Gallbladder Motility to Viscosity and Composition of Gallbladder Bile in Patients with Cholesterol Gallstones [PDF]

, 2009
Background/Aims: Increased viscosity and supersaturation of cholesterol in gallbladder bile, as well as an impaired motility of the gallbladder, are considered to be important factors in the pathogenesis of cholesterol gallstones.
Straub, Gundula, Juengst, Christoph, Schneider, Berthold, del Pozo, Reginald, Juengst, Dieter, Neubrand, Michael, Spelsberg, Fritz W., Althaus, Rupert, Gruendel, Denis, Huettl, Thomas P.   +9 more
core   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Effect of LncRNA GHET1 on Proliferation, Apoptosis, and Metastasis of Gallbladder Cancer Cells by Targeting miR-27b

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the effect of GHET1 on the biological behavior of gallbladder cancer cells and the regulatory mechanism of GHET1 on miR-27b. Methods The expression of GHET1 and miR-27b in 50 samples of gallbladder cancer was detected by real ...
YANG Zhen, LI Wenchuan, ZHOU Ning
doaj   +1 more source

Cholesterol nucleation time in gallbladder bile of patients with solitary or multiple cholesterol gallstones [PDF]

, 1992
Patients with multiple cholesterol gallbladder stones have been found to be at a higher risk for the recurrence of gallstones after successful nonsurgical treatment than those with a solitary stone.
Ritter, Christoph von, Paumgartner, Gustav, Pratschke, Ekkehard, Jüngst, Dieter, Lang, Thomas   +4 more
core   +1 more source

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

Hepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer   +2 more
wiley   +1 more source

Role of High total protein in gallbladder bile in the formation of cholesterol gallstones. [PDF]

, 1991
While it is generally accepted that cholesterol supersaturation of bile is of key importance in the rapid formation of cholesterol crystals, the role of total biliary protein and pH in the pathogenesis of cholesterol gallstones is less well understood ...
Ritter, Christoph von, Paumgartner, Gustav, Jüngst, Dieter, Lang, Thomas   +3 more
core   +1 more source

Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease [PDF]

, 1993
There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients.
Niemeyer, A., Ritter, C., Lange, V., Pozo, R., Meyer, L., Jüngst, Dieter, Richter, Werner O., Brandl, H., Möhrle, W.   +8 more
core   +1 more source