Results 251 to 260 of about 43,472 (345)

lncDILC Downregulation in Liver Cancer‐Associated Fibroblasts Drives Pro‐Invasive Conversion via a miR‐6071‐ZNF395 Axis

open access: yesCancer Science, Volume 117, Issue 1, Page 145-155, January 2026.
We found in the present study the loss‐of‐function of a sequential inhibitory cascade of lncDILC‐miR‐6071‐ZNF395 in liver CAFs, which promoted the NF‐CAF conversion through increasing expression of pro‐invasive cytokines like IL‐6, LIF, CXCL12, and TGF‐β.
Yawen Li   +7 more
wiley   +1 more source

SWI/SNF Chromatin Remodelling Complex in Hepatic Physiology: Mechanistic Insights Into Development, Homeostasis and Pathogenesis

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT The liver executes essential metabolic functions including energy homeostasis, lipid biosynthesis, cholesterol regulation and xenobiotic detoxification. While hepatocyte metabolic activity forms the foundation of these processes, their precise regulation is achieved through chromatin remodelling mechanisms, with the SWI/SNF complex emerging as
Rui Li   +4 more
wiley   +1 more source

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

open access: yesJournal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Maciej Gonciarz   +4 more
wiley   +1 more source

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