Results 131 to 140 of about 102,905 (309)

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Expressão gênica de ApoA1 e ApoB em de frangos de corte de duas linhagens diferentes

Medicina Veterinária, 2018
objetivo desse estudo foi avaliar a expressão gênica das apolipoproteínas A1 e B, bem como a relação entre elas no fígado de frangos de corte de duas linhagens, selecionada e não selecionada.
Angélica de Souza Khatlab, Stefânia Caroline Claudino da Silva, André Luiz Seccatto Garcia, Éverton Ferreira da Silva, Marcelise Fachinello, Eliane Gasparino   +5 more
doaj  

Mapping quantitative trait loci in Gallus gallus using principal components. [PDF]

, 2013
Projeto/Plano de Ação: 01.06.10.602 ...
COUTINHO, L. L., LEDUR, M. C., MOURA, A. S. A. M. T., NONES, K., PACKER, I. U., PINTO, L. F. B.   +5 more
core  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Сезонные колебания фагоцитарной активности лейкоцитов Gallus domesticus [PDF]

, 2013
На материале клетки дрожжей и вегетативной клетки сенной палочки исследовалась сезонная активность элементов системы крови и функциональные возможности лейкоцитов Gallus ...
Адамова, В. В., Бородаева, Ж. А., Буковцова, И. С., Чернявских, С. Д.   +3 more
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Les acariens du genre Megninia (Analgidae), parasites de Gallus gallus [PDF]

, 1985
On peut trouver sur les poulets domestiques l'une ou l'autre de trois espèces du genre Megninia : M. cubitalis (Mégnin 1877), M. ginglymura (Megnin 1877) et M. ortari, n. sp. ici décrite.
Atyeo, W.T., Barré, Nicolas, Gaud, J.
core