Results 71 to 80 of about 47,257 (306)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Agricultural ScienceCultivating gallus domestic and pama-khoy chicken varieties in Sadartengah Village is very profitable because the selling price is quite high for both gallus domesticus and pama-khoy chickens. Gallus domesticus and pama-khoy chicken varieties can be sold
Sri Purwanti +3 more
doaj +1 more source
The complete mitochondrial genome sequence of Lindian Chicken (Gallus gallus) in China
Mitochondrial DNA. Part B. Resources, 2018 In this study, the first complete mitochondrial genome of Lindian Chicken (Gallus gallus) was sequenced in order to develop the mitogenome data for genus gallus.
Yuan Xu +8 more
doaj +1 more source
A New Chicken Genome Assembly Provides Insight into Avian Genome Structure
G3: Genes, Genomes, Genetics, 2017 The importance of the Gallus gallus (chicken) as a model organism and agricultural animal merits a continuation of sequence assembly improvement efforts.
Wesley C. Warren +31 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Jakobus Gallus -/ Buike - Duo Seraphim - brass2, windmix - sheetmusic
, 2010 BB 92 - Jakobus Gallus (Handl / Peterlin) 1550-1591 - ed. et arr. Bruno Antonio Buike Duo Seraphim a 8 voc.
Bruno Buike, Jakobus Gallus
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Jakobus Gallus / Buike - Duo Seraphim - choir a 8 voc.- sheetmusic
, 2010 BB 90 - Jakobus Gallus (Handl / Peterlin) 1550-1591 - ed. et arr. Bruno Antonio Buike - Duo Seraphim a 8 voc. – choir SATB / SATB - colla parte:brass 1,2,3 BB 91.0 – 93.0 - concertpack with general score, choir 1, choir 2 ...
Bruno Buike, Jakobus Gallus
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Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source