Results 71 to 80 of about 5,752 (150)

The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity [PDF]

, 2016
Excessive reactive oxygen species/reactive nitrogen species (ROS/RNS) produced as a result of ageing causes damage to macromolecules and organelles or leads to interference of cell signalling pathways, which in turn results in oxidative stress. Oxidative
Chan, CB, Chen, H, Fang, Z, Liu, Z, Luo, W, Ma, S, Wang, C, Wang, H, Yang, Y, Zhang, Q   +9 more
core   +3 more sources

Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice

Advanced Science, Volume 12, Issue 30, August 14, 2025.
This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi   +16 more
wiley   +1 more source

Impact of Virus‐Mediated Modifications in Bacterial Communities on the Accumulation of Soil Organic Carbon

Advanced Science, Volume 12, Issue 30, August 14, 2025.
This study illustrates the impact of viruses on carbon cycling in soils with different availabilities of carbon. In conditions of low carbon availability, viruses adopt a lysogenic lifestyle, integrate into the host genomes and facilitate the degradation of carbon.
Mingfeng Liu, Guixiang Zhou, Congzhi Zhang, Lin Chen, Donghao Ma, Lijun Zhang, Chunhua Jia, Ling Ma, Jiabao Zhang   +8 more
wiley   +1 more source

The effect of spatial, spectral and radiometric factors on classification accuracy using thematic mapper data [PDF]

An experiment of a factorial design was conducted to test the effects on classification accuracy of land cover types due to the improved spatial, spectral and radiometric characteristics of the Thematic Mapper (TM) in comparison to the Multispectral ...
Acevedo, W., Alexander, D., Buis, J., Card, D., Wrigley, R. C.   +4 more
core   +1 more source

Long-term endurance and safety of elosulfase alfa enzyme replacement therapy in patients with Morquio A syndrome [PDF]

, 2016
Long-term efficacy and safety of elosulfase alfa enzyme replacement therapy were evaluated in Morquio A patients over 96weeks (reaching 120weeks in total from pre-treatment baseline) in an open-label, multi-center, phase III extension study.
AlSayed, MD, Berger, KI, Burton, BK, Giugliani, R, Guelbert, N, Harmatz, PR, Hendriksz, CJ, Hughes, DA, Jurecki, E, Matousek, R, Mitchell, JJ, Parini, R, Raiman, J, Shaywitz, AJ, Slasor, P, Solano Villarreal, ML, Stewart, F   +16 more
core   +1 more source

Shifts in the fungal community promote soil carbon accumulation in microaggregates during long‐term secondary succession

Functional Ecology, Volume 39, Issue 8, Page 2029-2043, August 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Secondary succession has been demonstrated as one of the effective restoration strategies for enhancing soil organic carbon (SOC) sequestration. Soil aggregates play a crucial role in SOC sequestration by providing habitats for microbes and physically protecting SOC ...
Yangquanwei Zhong, Baoping Zhang, Yuanjun Zhu, Zhouping Shangguan, Tiantian Li, Lei Deng, Ji Chen, Weiming Yan   +7 more
wiley   +1 more source

Evaluation of the CRISPR/Cas9 system as genome editing platform for the Mucopolysaccharidosis IV A using a strategy for induction of higher homologous recombination frequency

Universitas Scientiarum
Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the gene encoding for the hydrolase N-acetylgalactose-6-sulfate sulfatase (GALNS). GALNS deficiency leads to a progressive buildup of partially degraded chondroitin-
Diego Alejandro Suarez, Andrés Felipe Leal, Carlos Javier Alméciga Díaz   +2 more
doaj   +1 more source

Clinical and molecular characteristics of colombian patients with mucopolysaccharidosis IVA, and description of a new galns gene mutation

Molecular Genetics and Metabolism Reports, 2018
A study published in 2012 estimated incidence of MPS IVA, in 0.68 cases per 100, 000 live births in Colombia, and according to the Colombian Fund for High-Cost Diseases, in 2014 there were 15 people diagnosed with MPS IV.
Lina Johanna Moreno Giraldo, Ángela María Escudero Rodríguez, Adalberto Sánchez Gómez, José María Satizabal Soto   +3 more
doaj   +1 more source

Spatial distribution and driving factors of microbial necromass carbon in coastal wetlands of China

Functional Ecology, Volume 39, Issue 8, Page 2056-2069, August 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Microbial necromass carbon (MNC) constitutes a vital component of soil carbon pools and plays an essential role in the global soil carbon cycle. However, the mechanisms driving MNC concentration in coastal wetlands, particularly across different habitat types (such as ...
Jiawei Zhang, Xiao Yang, Wei Wang, Huajie Dong, Yuan Xu, Xinpeng Fan   +5 more
wiley   +1 more source

Long-term therapeutic efficacy of allogenic bone marrow transplantation in a patient with mucopolysaccharidosis IVA

Molecular Genetics and Metabolism Reports, 2014
Mucopolysaccharidosis IVA (MPS IVA) is one of the lysosomal storage diseases. It is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase.
Yasutsugu Chinen, Takeshi Higa, Shunji Tomatsu, Yasuyuki Suzuki, Tadao Orii, Nobuyuki Hyakuna   +5 more
doaj   +1 more source