Results 81 to 90 of about 4,684 (195)

Chlorella Polysaccharide Extract Attenuates Skin Aging via MAPK Pathway Suppression: Implications for Cosmetic Dermatology

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Chlorella polysaccharide extract (CPE) is a natural compound with known antioxidant and immunomodulatory properties. This study investigated its anti‐aging potential and underlying mechanism, with a focus on dermatological relevance.
Minghui Zhang, Yaling Guo, Xufeng Jiang, Zhouxin Li, Guanggang Xiang, Yewen Lin, Yang Zhang   +6 more
wiley   +1 more source

Ricinus Communis: Nutritional Importance, Health Benefits, and Industrial Applications

eFood, Volume 7, Issue 1, February 2026.
The current paper summarizes the nutritional composition, phytochemistry, health benefits, safety studies, and applications of castor beans and their oil. Moreover, the diverse bioactive compounds, including saponins, emodins, terpenoids, anthraquinones, flavonoids, steroids, and alkaloids, exhibit therapeutic properties such as antioxidant, anticancer,
Hassan Raza, Muhammad Tauseef Sultan, Asad Abbas, Aimen Mazhar, Ahmad Mujtaba Noman, Muhammad Imran, Muzzamal Hussain, Ehab M. Mostafa, Ahmed H. El‐Ghorab, Mohammed M. Ghoneim, Samy Selim, Mohamed A. Abdelgawad, Anjuman Gul Memon, Entessar Al Jbawi   +13 more
wiley   +1 more source

Identification of Ezetimibe and Pranlukast as Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA

, 2019
Mucopolysaccharidosis type IVA (MPS IVA) is a rare disease caused by mutations in the gene encoding the lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS).
Andrés Felipe Rojas-Rodriguez (6872237), Sergio Olarte-Avellaneda (6872219), Luisa Natalia Pimentel-Vera (6872231), Alexander Rodríguez-López (6872222), Esteban Guzman (6872225), Rong Li (72042), Carlos J. Alméciga-Diaz (6872213), Rafael Garzón (6872228), María Alejandra Puentes-Tellez (6872234), Oscar A. Hidalgo (6872216), Kirill Gorshkov (5752142), Wei Zheng (25452)   +11 more
core   +3 more sources

A 9-Month-Old with Skeletal Abnormalities and a Consanguineous Sibling with Mucopolysaccharidosis IVA: The Role of Urinary Glycosaminoglycan Testing in Disease Diagnosis and Treatment Monitoring

Clinical Medicine Insights: Case Reports, 2021
Mucopolysaccharidosis IVA (MPS IVA) is a rare autosomal recessive lysosomal storage disorder resulting from N-acetylgalactosamine-6-sulfatase (GALNS) deficiency that occurs in approximately 1 in 76 000 to 1 in 640 000 live births.
Eric Goldman, Angela Vu, Kelly Dietz, Stefani N Thomas   +3 more
doaj   +1 more source

Pathogenic Variants in Mennonites From Southern Brazil: Implications for Preventive Measures in Public Health

Clinical Genetics, Volume 109, Issue 2, Page 266-276, February 2026.
In 325 exomes of South Brazilian Mennonites, we identified 23 pathogenic variants (P) and 27 likely P, with founder effects identified for 96% of P, whose frequencies differed from non‐Finnish Europeans, Amish, and Brazilian populations. ABSTRACT The Mennonite population has a unique history of 500 years of genetic isolation shaped by at least three ...
Luiza Beatriz Mayer de Lima, Eduardo Delabio Auer, Isabela Dall’Oglio Bucco, Valéria Bumiller‐Bini Hoch, Priscila Ianzen dos Santos, Fabiana L. Lopes, Alan Shuldiner, Emilton Lima Júnior, Angelica Beate Winter Boldt   +8 more
wiley   +1 more source

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Uso de vectores derivados de virus adenoasociados para el tratamiento de la enfermedad de Morquio A

Revista Universitas Medica, 2009
En el desarrollo de una estrategia de terapia génica para la mucopolisacaridosis IV A (enfermedad de Morquio A), en el presente trabajo se evaluó la capacidad de un vector adenoasociado (AAV) para expresar el gen de la enzima sulfatasa N ...
CARLOS JAVIER ALMÉCIGA-DÍAZ, MARÍA ANDREA RUEDA-PÁRAMO, OLGA YANETH ECHEVERRI, ADRIANA MARÍA MONTAÑO, SHUNJI TOMATSU, LUIS ALEJANDRO BARRERA   +5 more
doaj  

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

Molecular analysis in a GALNS study cohort of 15 Tunisian patients: description of a novel mutation [PDF]

Diagnostic Pathology, 2016
داء عديدات السكاريد المخاطي من النوع IVA (MPS IVA) هو مرض جسدي متنحي ناتج عن نقص إنزيم الليزوزوم N - acetylgalactosamine -6 - sulfate sulfatase (GALNS). كان الغرض من هذه الدراسة هو تحليل طفرات GALNS والأنماط الفردية المرتبطة بها. تم إجراء فحص الطفرة لجين GALNS عن طريق تحليل التسلسل المباشر باستخدام عينات الحمض النووي من 15 مريضًا تونسيًا غير مرتبطين بـ
Latifa Chkioua, Souhir Khedhiri, Hind Hafsi, Oussama Grissa, Hadhami Ben Turkia, Abdelhédi Miled, Sandrine Laradi, Roseline Froissart, Najat Alif   +8 more
openaire   +2 more sources

Anaerobic sulfatase maturase AslB from Escherichia coli activates human recombinant iduronate-2-sulfate sulfatase (IDS) and N-acetylgalactosamine-6-sulfate sulfatase (GALNS)

, 2020
Maturation of type I sulfatases requires the conversion of the cysteine (Cys) or serine (Ser) present in the active site to formylglycine (FGly). This activation represents a limiting step during the production of recombinant sulfatases in bacteria and ...
Bonilla Y.A., Alméciga-Díaz C.J., Espejo-Mojica A.J., Sánchez O.F., Gonzalez-Santos J., Tolosa-Díaz A.D., Pimentel L.N., Patiño J.D., Rodríguez-López A.   +8 more
core   +1 more source