Results 21 to 30 of about 8,693 (164)

Growth Rate of Transgenic Pigs and Size of Pig Hearts for Xenotransplantation to Cynomolgus Monkey

Journal of Animal Reproduction and Biotechnology, 2014
To compensate for the critical shortage of human organs for allotransplantation, xenotransplantation studies using genetically modified pigs are being performed in Korea.
Sun A Ock, Keon Bong Oh, Seongsoo Hwang, Jungkyu Lee, Youngim Kim, Sun-Woung Moon, Dae-Jin Kwon, Ik Jin Yun, Eungwoo Park   +8 more
doaj   +1 more source

Molecular Characterization of Galactosemia: Identification of Six Novel GALT Gene Mutations

Gene, Cell and Tissue, 2022
Background: Classic galactosemia (CG) is an inborn error of galactose metabolism caused by a deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT). This enzyme causes the conversion of uridine diphosphate- glucose (UDP)-glucose and galactose-1-phosphate (Gal-1-P) to glucose-1-phosphate and UDP-galactose.
Mehrnoosh Moody, Mojgan Hosseini, Abdolkhalegh Deezagi, Parichehreh Yaghmaei, Massoud Houshmand   +4 more
openaire   +1 more source

Characterization of an unusual deletion of the galactose-1-phosphate uridyl transferase (GALT) gene [PDF]

Genetics in Medicine, 2006
We previously reported a deletion of the Galactose-1-Phosphate Uridyl Transferase (GALT) gene. This deletion can cause apparent homozygosity for variants located on the opposite allele, potentially resulting in a discrepancy between the biochemical phenotype and the apparent genotype in an individual.
Bradford, Coffee, Lawrence N, Hjelm, Angela, DeLorenzo, Ebony M, Courtney, Chunli, Yu, Kasinathan, Muralidharan   +5 more
openaire   +2 more sources

Changes in the gene expression and methylation in chicken cecal tonsils after in ovo administration of bioactive substances

Scientific Reports, 2023
Cecal tonsils are the main organs which generate an immune response and also the part of the GALT, thus they are in the close proximity of the intestinal microbiota and continuously exposed to microbe-associated molecular patterns.
Aleksandra Dunislawska, Magdalena Gryzinska, Maria Siwek   +2 more
doaj   +1 more source

Experiences with galactosemia in Croatia [PDF]

Liječnički vjesnik, 2023
The aim of our study was to describe the characteristics of patients with classical galactosemia in Croatia, with the description of patients with galactokinase deficiency and a patient who was a double heterozygote for mutations of the galactose-1 ...
Ana Šmaguc, Danijela Petković Ramadža, Vladimir Sarnavka†, Vjekoslav Krželj, Bernarda Lozić, Silvija Pušeljić, Valentina Rahelić, Nikola Mesarić, Marina Grubić, Ana Bogdanić, Anita Špehar Uroić, Tamara Žigman, Ruža Grizelj, Jurica Vuković, Duško Mardešić, Ildiko Szatmari, Isabel Rivera, Ksenija Fumić, Ivo Barić   +18 more
doaj   +1 more source

Functional analysis of GALT variants found in classic galactosemia patients using a novel cell‐free translation method

JIMD Reports, 2019
Classic galactosemia is an autosomal recessive disorder caused by deleterious variants in the galactose‐1‐phosphate uridylyltransferase (GALT) gene. GALT enzyme deficiency leads to an increase in the levels of galactose and its metabolites in the blood ...
Daffodil M. Canson, Catherine Lynn T. Silao, Salvador Eugenio C. Caoili   +2 more
doaj   +1 more source

Transdifferentiation of α-1,3-Galactosyltransferase Knock Out (GalT KO) Pig Derived Bone Marrow Mesenchymal Stromal Cells (BM-MSCs) into Pancreatic Cells by Transfection of hPDX1

Journal of Animal Reproduction and Biotechnology, 2015
Diabetes mellitus, the most common metabolic disorder, is divided into two types: type 1 and type 2. The essential treatment of type 1 diabetes, caused by immune-mediated destruction of β-cells, is transplantation of the pancreas; however, this treatment
Sun A Ock, Keon Bong Oh, Seongsoo Hwang, Youngim Kim, Dae-Jin Kwon, Gi-Sun Im   +5 more
doaj   +1 more source

Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota

Journal of Immunology Research, 2022
Gut-associated lymphoid tissue (GALT), such as Peyer’s patches (PPs), are key inductive sites that generate IgA+ B cells, mainly through germinal center (GC) responses.
Masato Tsuda, Hiraku Okada, Natsuki Kojima, Fumiya Ishihama, Yuhei Muraki, Toshiki Oguma, Nanako Hattori, Takumi Mizoguchi, Kiyoaki Mori, Satoshi Hachimura, Yoshimasa Takahashi, Kyoko Takahashi, Shuichi Kaminogawa, Akira Hosono   +13 more
doaj   +1 more source

Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota. [PDF]

PLoS ONE, 2012
Pigeon 'milk' and mammalian milk have functional similarities in terms of nutritional benefit and delivery of immunoglobulins to the young. Mammalian milk has been clearly shown to aid in the development of the immune system and microbiota of the young ...
Meagan J Gillespie, Dragana Stanley, Honglei Chen, John A Donald, Kevin R Nicholas, Robert J Moore, Tamsyn M Crowley   +6 more
doaj   +1 more source

Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation

Disease Models & Mechanisms, 2016
Classic galactosemia (CG) is a potentially lethal inborn error of metabolism that results from the profound loss of galactose-1-phosphate uridylyltransferase (GALT), the second enzyme in the Leloir pathway of galactose metabolism.
Jennifer M. I. Daenzer, Patricia P. Jumbo-Lucioni, Marquise L. Hopson, Kerry R. Garza, Emily L. Ryan, Judith L. Fridovich-Keil   +5 more
doaj   +1 more source