Results 51 to 60 of about 228,801 (264)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Playing Games with Timed Games [PDF]
IFAC Proceedings Volumes, 2009 In this paper we focus on property-preserving preorders between timed game automata and their application to control of partially observable systems. Following the example of timed simulation between timed automata, we define timed alternating simulation as a preorder between timed game automata, which preserves controllability.
Chatain, Thomas +2 more
openaire +3 more sources
Assimilation of surface soil moisture into a multilayer soil model: design and evaluation at local scale [PDF]
Hydrology and Earth System Sciences, 2014 Land surface models (LSM) have improved considerably in the last two decades. In this study, the Interactions between Surface, Biosphere, and Atmosphere (ISBA) LSM soil diffusion scheme is used (with 11 soil layers represented).
M. Parrens +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
ACM Transactions on Computational Logic, 2018 We introduce and study Minkowski games. These are two-player games, where the players take turns to choose positions in R<sup<d</sup< based on some rules. Variants include boundedness games, where one player wants to keep the positions bounded, and the other wants to escape to infinity; as well as safety games, where one player wants to ...
Stéphane Le Roux 0001 +2 more
openaire +10 more sources
WINTER MORTALITY AND SUPPLEMENTAL FEEDING OF TURKEYS IN PENNSYLVANIA
Wildlife Society Bulletin, 1975 : During a 12 year study in northcentral Pennsylvania, wild turkeys (Meleagris gallopavo silvestris) starved in four winters when extended periods of deep powder snow prevented their foraging for food. More than half the turkeys at higher elevations died,
Gerald A. Wunz, Arnold H. Hayden
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Pan African Medical Journal, 2020 We report the case of a 13-year-old child who presented to the ophthalmic emergencies for left eye trauma because of a sore eyelid, while fighting with one of his classmates using pairs of scissors. The clinical examination found a wound on the upper left eyelid with loss of substance of the skin without involvement of the orbicularis muscle (A ...
Kawtar Belkhadir, Ouafaa Cherkaoui
openaire +4 more sources
Game—The Dressing Change Game [PDF]
INFORMS Transactions on Education, 2015 Many employees face operational failures—missing or insufficient supplies, equipment, information, and personnel—that interfere with their workflow and can negatively impact organizational performance. However, employees often devise methods to work around these obstacles that may come with negative side effects.
Anita L. Tucker, Cindy Lefton
openaire +1 more source
SensorsAchieving high attack success rate (ASR) with minimal perturbed distortion has consistently been a prominent and challenging research topic in the field of adversarial examples.
Yi Zhang +4 more
doaj +1 more source