Results 51 to 60 of about 10,106,235 (292)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A Hexagon Sensor and A Layer-Based Conversion Method for Hexagon Clusters

Information
In reinforcement learning (RL), precise observations are crucial for agents to learn the optimal policy from their environment. While Unity ML-Agents offers various sensor components for automatically adjusting the observations, it does not support ...
Jun-Ho Kim, Hanul Sung
doaj   +1 more source

Research through game design: interactive stories from a submerged Amsterdam [PDF]

, 2018
Deciding what kind of smart cities do we, as a society, want is not only a political question but also a matter of envisioning possible futures. The speculative narratives that designers produce to support their imagination are called "Design Fictions ...
Korte, Genèviéve, Gabriele Ferri, Genèviéve Korte, Ferri, Gabriele   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mechanism Design of Magnetic-Assistance in Surface Finishing of End-Turning

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2008
A new mechanism design using a magnetic force with high efficiency to assist discharging dregs out of the electrode gap during the electrochemical finishing on the surface finish process that follows end-turning is investigated in the current study ...
Pai-Shan PA
doaj   +1 more source

Artificial intelligence in the digital twins: State of the art, challenges, and future research topics [version 2; peer review: 2 approved]

Digital Twin, 2022
Advanced computer technologies such as big data, Artificial Intelligence (AI), cloud computing, digital twins, and edge computing have been applied in various fields as digitalization has progressed.
Zhihan Lv, Shuxuan Xie
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Serious Games in Science Education: A Systematic Bibliometric and Content Analysis

Computers
This study examines recent research trends in the use of serious games for science education through a bibliometric analysis of 340 articles and a qualitative content analysis of 56 studies published between 2020 and 2025 in the Web of Science Core ...
Deniz Poyraz Gök, Nuri Kara
doaj   +1 more source

Wearable Sensors for Vital Signs Measurement: A Survey

Journal of Sensor and Actuator Networks, 2022
With the outbreak of coronavirus disease-2019 (COVID-19) worldwide, developments in the medical field have aroused concerns within society. As science and technology develop, wearable medical sensors have become the main means of medical data acquisition.
Zhihan Lv, Yuxi Li
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source