Results 41 to 50 of about 194,492 (310)

Artificial intelligence in the digital twins: State of the art, challenges, and future research topics [version 2; peer review: 2 approved]

open access: yesDigital Twin, 2022
Advanced computer technologies such as big data, Artificial Intelligence (AI), cloud computing, digital twins, and edge computing have been applied in various fields as digitalization has progressed.
Zhihan Lv, Shuxuan Xie
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

On Making Good Games - Using Player Virtue Ethics and Gameplay Design Patterns to Identify Generally Desirable Gameplay Features [PDF]

open access: yes, 2010
This paper uses a framework of player virtues to perform a theoretical exploration of what is required to make a game good. The choice of player virtues is based upon the view that games can be seen as implements, and that these are good if they ...
Björk, Staffan, Bj\uf6rk, Staffan
core  

A Hexagon Sensor and A Layer-Based Conversion Method for Hexagon Clusters

open access: yesInformation
In reinforcement learning (RL), precise observations are crucial for agents to learn the optimal policy from their environment. While Unity ML-Agents offers various sensor components for automatically adjusting the observations, it does not support ...
Jun-Ho Kim, Hanul Sung
doaj   +1 more source

Wearable Sensors for Vital Signs Measurement: A Survey

open access: yesJournal of Sensor and Actuator Networks, 2022
With the outbreak of coronavirus disease-2019 (COVID-19) worldwide, developments in the medical field have aroused concerns within society. As science and technology develop, wearable medical sensors have become the main means of medical data acquisition.
Zhihan Lv, Yuxi Li
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Let the Body’n’Brain Games Begin: Toward Innovative Training Approaches in eSports Athletes

open access: yesFrontiers in Psychology, 2020
The phenomenon of eSports is omnipresent today. International championships and their competitive athletes thrill millions of spectators who watch as eSports athletes and their teams try to improve and outperform each other.
Anna Lisa Martin-Niedecken   +1 more
doaj   +1 more source

A Sentiment Analysis of Turkish Tweets Shared in Nursing Week During the Pandemic

open access: yesSağlık ve Hemşirelik Yönetimi Dergisi, 2022
Aim: This study aimed to conduct an artificial intelligence-based sentiment analysis of Turkish tweets about nursing during the nursing week during the COVID-19 pandemic. Method: This is a retrospective descriptive survey. Between May 4 and May 19, 2021,
Muzaffer Berna Doğan   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Terms of Service: Coming to Terms with AI-Generated Art in the Classroom’ [PDF]

open access: yesAthens Journal of Humanities & Arts
This paper describes the plan and design of a new course, entitled “AI & Art.” The course introduces select tools made possible by generative artificial intelligence and large language models (LLMs).
Gregory P. Garvey
doaj   +1 more source

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