Results 271 to 280 of about 1,275,875 (318)

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

open access: yesAdvanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song   +13 more
wiley   +1 more source

Advancing Soil Organic Carbon Prediction: A Comprehensive Review of Technologies, AI, Process‐Based and Hybrid Modelling Approaches

open access: yesAdvanced Science, EarlyView.
This review highlights advances in soil organic carbon (SOC) quantification using remote sensing, proximal soil sensing, AI (ML and DL), and biogeochemical modelling. Integrating diverse data sources and models improves SOC prediction accuracy. Key priorities include enhancing data availability, refining models, incorporating microbial processes, and ...
Zijuan Ding   +16 more
wiley   +1 more source

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

open access: yesAdvanced Science, EarlyView.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen   +17 more
wiley   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

open access: yesAdvanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye   +13 more
wiley   +1 more source

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